【正文】 作為五類中藥注射劑新藥，該課題主要解決中藥紅花有效成分富集技術(shù)問題，提高產(chǎn)品的有效性。 圖：諾華醋酸奧曲肽的全球銷售額增長情況。按照每年5%6%的速度增長，20092011年的三年間，抗結(jié)核病藥將會有約10億元的市場規(guī)模。：利福霉素（Rifamycin）是意大利萊佩蒂（Lepetit）研究所從鏈球菌發(fā)酵培養(yǎng)液中分離出的一種抗生素，1962年開始用于臨床，商品名為Rifocin。經(jīng)過試驗數(shù)據(jù)比較：在25 平方米生產(chǎn)線上，傳統(tǒng)的壓縮機凍干機每凍干一批藥品，需要活塞壓縮機3 臺，冷卻水給水泵1 臺， 冷卻塔電機1 臺， 千瓦。中國政府在哥本哈根氣候會議上承諾到2020年比2005年減少CO2排放4045%。, Tetrahedron, 2001, 57 (14), 27112715.2. Yan ., Terashima K., Takaya Y., Niwa M., Two new stilbenetetramers from the stem of Vitis vinifera 39。任公司董事長。單位基本情況：：廣東星昊藥業(yè)有限公司（原名：中山聯(lián)合偉華藥業(yè)有限公司）為北京星昊醫(yī)藥股份有限公司投資新建的重要的藥品生產(chǎn)基地，位于廣東省中山市國家健康科技產(chǎn)業(yè)基地，㎡?！?132……………………………………………………31……………………………………………………32二．項目可行性研究報告及專家論證意見、環(huán)境影響評價報告書。 his contemporary Evelyn Waugh stated that the West Africa of that book replaced the true remembered West Africa of his own experience. Such power is not unmon: the Yorkshire moors have been romanticized because Emily Bronte wrote of them in Wuthering Heights, and literary tourists have visited StokeonTrent in northern England because it prises the “Five Towns” of Arnold Bennet’s novels of the early twentieth century. Thus, a reader’s reaction to a place is not merely based upon the way it looks, but upon the potentialities of action suggested by it. Places matter greatly to many writers. For instance, the French novelist Balzac, before writing a story set in a town, he would go and visit that town, select a few lanes and houses, and describes them in detail, down to their very smells. In his view the place in which an event occurs was of equal moment with the event itself, and it has a part to play. Another example is Thomas Hardy, under whom the presentation of setting assumes an unusual importance. His “Wessex” villages cast intangibly such as spell upon the villagers that once they leave their hometowns they will inevitably suffer from disasters, and the farther they are away from their hometowns, the more, terrible their disasters will be. For example, in the Tess of the D’Urbervilles, the Vale of Blakemore was the place where Tess was born and her life was to unfold. Every contour of the surrounding hills was as personal to her as that of her relatives’ faces。Does the author (through the narrator) make any general observations about life or human nature? Do the characters make any (Caution: Characters now and again will utter opinions with which the reader is not necessarily supposed to agree.)Does the story contain any especially curious objects, mysterious flat characters, significant animals, repeated names, special allusions, or whatever, that hint towards meanings larger than such things ordinarily have? In literary stories, such symbols or metaphors may point to central themes. she loved the place and was loved in the place. The vale, far from the madding crowd of the civilized city, was as serene and pure as the inhabitants. Tess, imbued deeply with the natural hue of the vale and bound closely to this world of simplicity and seclusion, experienced her own delight and happiness though her family was poor. It was, to some extent, her departure from her native place that led to her tragedy. In The Return of the Native, the atmosphere of Egdon Heath prevails over the whole book。三．項目的備案、核準或?qū)徟募?。生產(chǎn)線建成后將主要從事凍干粉針劑、小容量注射液、塑料安瓿注射液、化學原料藥以及中藥提取的中試與生產(chǎn)。在麗珠集團股份有限公司工作期間，主持多個新藥開發(fā)項目，其中數(shù)個品種目前已成為麗珠醫(yī)藥集團的拳頭產(chǎn)品，于2000年10月創(chuàng)建了北京星昊醫(yī)藥股份有限公司（原北京星昊現(xiàn)代醫(yī)藥開發(fā)有限公司），憑借她多年主持新藥開發(fā)的經(jīng)驗和與國際接軌的管理水平，積極了解國內(nèi)外相關(guān)領(lǐng)域的發(fā)展動態(tài)，以新型的管理方法和經(jīng)營理念來設(shè)計公司的發(fā)展。Kyohou,39。目前，國內(nèi)工業(yè)制藥凍干技術(shù)均采用氟利昂制冷及其回收技術(shù)，凍干過程中耗電耗水多， 制造成本高。如果年生產(chǎn)150批次則全年耗電：249480千瓦時。主要用于革蘭氏陽性菌引起的感染及結(jié)核分枝桿菌引起的感染。利福霉素鈉注射劑憑借其耐多藥、快速高效、高生物利用度等特點，已在抗結(jié)核領(lǐng)域取得了絕對的市場份額，如果以35%市場份額計算的話。國內(nèi)市場，據(jù)統(tǒng)計，2001年、2002年、,逐年增加。同時采用特定的工藝去除能引起過敏的植物性大分子物質(zhì)，保證注射劑的安全性。該病分為5種類型，即難治性貧血（RA）、環(huán)形鐵粒幼細胞性難治性貧血、難治性貧血伴原始細胞增多（RAEB）、難治性貧血伴原始細胞增多轉(zhuǎn)變型（RAEBT）及慢性粒單核細胞白血?。–MML）。我們公司的注射用紅花黃色素由于先進技術(shù)的投入，將有望成為良好的高效低毒、適于急救的心腦血管用藥，為廣大心腦血管疾病患者帶來福音。作為一個專利過期藥，醋酸奧曲肽在國際市場的一直保持約10%的增長表明國際市場仍然有巨大的空間（如表1）。其中，%，遠遠領(lǐng)先第二位（%）（數(shù)據(jù)來源：中國制藥信息，22卷第8期）。：星昊醫(yī)藥現(xiàn)有的注射劑生產(chǎn)產(chǎn)能已遠遠不足以滿足商業(yè)客戶的需求，其中包括注射用利福霉素鈉、注射用奧曲肽等具有顯著的工藝、質(zhì)量、成本優(yōu)勢的高附加值產(chǎn)品。而且由于沒有了壓縮機,用電的總耗量也減少了一半以上。 、節(jié)能減排、保護環(huán)境的需要：中國“十一五”規(guī)劃綱要提出“節(jié)能減排”的工業(yè)方針政策，要求“十一五”期間單位國內(nèi)生產(chǎn)總值能耗降低20％左右、主要污染物排放總量減少10％。Kyohou39。曾任職于麗珠醫(yī)藥集團股份有限公司及其下屬企業(yè)。：2010年9月2011年2月； 設(shè)備進廠、安裝及調(diào)試等： 2011年2月 2011年6月、注射用奧曲肽投產(chǎn)及委托加工：2011年7月：2012年7月、替加環(huán)素、甲磺酸萘莫司他：從2013年1月起陸續(xù)投產(chǎn)。In some stories, a writer seems to draw a setting mainly to evoke atmosphere. In such a story, setting starts us feeling whatever the storyteller would have us feel. Thus atmosphere is a metaphor for a feeling or an impression which we cannot readily attach to some tangible cause. We say that an old farmhouse set among large maples, on a green lawn, has an atmosphere of peace. Here what we mean is that the house, by reason of the look of quietness and by reason of a number of pleasant associations we have with the kind of life lived there, stirs a certain reaction in us which we do not attach to any single incident or object, but generally to the whole scene. In the same way we may say that the setting of a story contributes to defining its atmosphere. For instance, in “The TellTale Heart,” Poe’s setting the action in an old, dark,廣東省戰(zhàn)略性新興產(chǎn)業(yè)發(fā)展專項資金單個企業(yè)項目申請報告 （生物制藥）項目名稱：原料藥、藥物制劑生產(chǎn)線建設(shè)項目承擔單位：廣東星昊藥業(yè)有限公司聯(lián)系地址：中山火炬開發(fā)區(qū)國家健康基地內(nèi)健康路17號聯(lián)系人:聯(lián)系電話：郵政編碼：2010年11月目 錄一．項目概述項目概述………………………………………………………………4………………………………………………………………5………………………………………………………… 5………………………………………………… 5…………………………………… 5…………………… 5……………… 5 ………………………………………………………5單位基本情況 ……………………………………………………… 5……………………………………………………… 56…………………………………………………………7………………………………………………………78……………………………………………9………………………………………………9………………………………………………………912建設(shè)內(nèi)容 …………………………………………………………13投資規(guī)模 …………………………………………………………13資金來源 …………………………………………………………14申請理由與方向 …………………………………………………14 ………………………………………………………1節(jié)能減排、保護環(huán)境的需要………………1416 ………………17 …………………………………………17…………………1718…………………………1920………………………20…………………21……………………2223……………………2324………………………………25………2526分年度詳細預算（附具體預算方案）………