【正文】 (54y) A. Kornberg (41y) Isolation of DNA polymerase I The Nobel Prize 1959 遺傳學(xué)和生物化學(xué)是 分子生物學(xué) 發(fā)展的根基 分子生物學(xué) 是遺傳學(xué)和生物化學(xué)融合的結(jié)果 研究遺傳物質(zhì)－基因的本質(zhì) 理解基因調(diào)控生化代謝過程 進(jìn)入 . 分子生物學(xué)史的 第一個重要發(fā)現(xiàn) One gene － One enzyme 1941年， Gee Beadle和 Edward Tatum Neurospora crassa （粉色面包霉菌） 提出的“ one gene ─ one enzyme”的假說 （ 獲得 1958年 Nobel獎 ） 說明了基因的生化作用本質(zhì)是控制酶的合成 G. Beadle amp。它應(yīng)該在 60年代 后被建立起來 ?。? 而且當(dāng)時 J. Lederberg和 A. Kornberg就已經(jīng)討論過用“ DNA聚合酶獲取大量 DNA的可能性”。s Nobel Prize in Chemistry jointly to Sidney Altman and Thomas R. Cech for their discovery of catalytic properties of RNA Sidney Altman Yale University New Haven, CT, USA Thomas R. Cech University of Colorado at Boulder, USA Contents: Introduction The chemistry of life and its central dogma Enzymes – biological catalysts Ribonucleic acid (RNA) – the biomolecule which can do it all The history of biocatalysis What happens next? Further reading Based on materials from the 1989 Nobel Poster for Chemistry. Credits and references for the poster Last modified May 10, 2022 Copyright?2022 The Nobel Foundation The Official Web Site of The Nobel Foundation The Nobel Prize in Chemistry 1989 for their discovery of catalytic properties of RNA Ribozyme Sidney Altman Thomas R. Cech Yale University New Haven, CT, USA University of Colorado Boulder, CO, USA 1939 1947 The NP 1993 split genes In 1978 Richard J. Roberts Phillip A. Sharp mini revolution discovered Geic control of early development in Drosophila Edward B. ewis Christiane N252。 哈佛大學(xué)校長談哈佛特點 : 學(xué)生從教師從課堂中學(xué)到的知識 =40% 學(xué)生自學(xué)和從同學(xué)中學(xué)到的知識 =60% 基本概念 + 邏輯分析