手性有機(jī)小分子催化的不對(duì)稱(chēng)合成反應(yīng)(更新版)
【正文】 oxidation Asymmetric dihydroxylation Asymmetric hydroxyamination 2022 Nobel Prize for Metalcatalyzed William S. Knowles Asymmetric Hydrogenation Ryoji Noyori Ruthenium catalyzed Hydrogenation and PTH Asymmetric Synthesis 脯氨酸催化的 Aldol反應(yīng) HOO P r o l i n es o l . , r t .OO HX XList et al, JACS, 2022 HR 1OH R 2O L P r o l i n e ( 0 . 1 e q . ) D M F , 4 o C H R2R 1O HOd o n o r a c c e p t o rMacMillan et al, JACS, 2022 ee% up to 96% ee% up to 99% Reaction Mechanism 脯氨酸衍生物 NNOXP hP hHHORHG o n g W u c a t a l y s tf o r a l d o l r e a c t i o n sX = N , OR HO Oc a t ( 0 . 2 e q ) 2 5 oCROO HNH H NOH OP hP h G o n g W u c a t a l y s tu p t o 9 9 % e eGong et al, JACS, 2022 OC l 3 CONHNHNNNOC C l 3O HR( 5 % m o l ), 4 0 o C , 2 4 hc a t .Y a m a m o t o c a t a l y s tUp to 99% ee Yamamoto et al, . 2022 HORHON O2c a t . ( 0 . 1 e q . )D M S O , r t , 4 8 h HON O2RO HNNR2R1HOA r HC F3C O2HOA rR2R1O HUp to 96% ee Barbas III et al, Angew. Chem. 2022 Mannich反應(yīng) ON O 2C H O N H 2O M eO H NO M eN O 2L P r o l i n e ( 0 . 3 5 e q . )D M S Oup to 99% ee ON H P M PC O 2 E tOC O 2 E tN H P M PNNNNNNC O 2 E tHHP M PR 2R 1NH H NNNNc a t . ( 0 . 0 5 e q . )s o l . , r t , 2 h ru p t o 9 9 % e eList et al, JACS, 2022 Ley et al, Synlett, 2022 ?氨基化反應(yīng) HR 1ONNR 2 O 2 CC O 2 R 2L P r o l i n e r t HONC O 2 R 2H NC O 2 R 2R 1NOOR 2 O 2 CONN C O 2 R 2OR 1HR 1R 2ONNE t O 2 CC O 2 E tL P r o l i n e r t R 1ONC O 2 E tH NC O 2 E tR 2NOOR 1E t O 2 CONN C O 2 E tOR 2HJ248。N HN NSA rA r SH HR1NHOR2ORR
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號(hào)-1