中山大學(xué)循證醫(yī)學(xué)evidencebasedmedicine_zsu_fs(完整版)
【正文】 nostic Performance Diagnostic Impact Therapeutic Impact Impact on Health Source of Medical Information ? Colleagues ? Conferences ? Drug Reps ? Textbooks ? Journals ? Inter/Patients Source of Medical Information ? Primary – MEDLINE， CBM ? Secondary – Guidelines， Cochrane Lib ? Much more likely (than personal search and critical appraisal) to be true ? Saves the clinician’s time – Textbook ? Others？ – Conference – Institutional or personal experience Source of Medical Information ? Interest group or anization ? Commercial Company’s News or Brief ? Google, Yahoo! …… Open Mind and Be Very Carefully Quick Information ? Guidelines – Explicit evidencebased – Evidencebased – Researchbased (highly referenced) – Opinionbased – “expert consensus” National Guideline Clearinghouse ( Cancer Care Ontario39。 ? 2022年 – 國家藥品監(jiān)督管理局（ SDA）批準(zhǔn)中華靈芝寶轉(zhuǎn)為“國藥準(zhǔn)字” B20220428，并更名為“雙靈固本散”。課題，結(jié)論證實該藥物對 多種白血病和人體實體癌細胞 具有明顯的抑制作用，并呈現(xiàn)較好的量效關(guān)系。s Program in EvidenceBased Care (PEBC) and the Cancer Care Ontario Practice Guidelines Initiative (CCOPGI) Quick Information ? Cochrane Library The Cochrane Collaboration – Systematic reviews – The current resource with the highest methodological rigor – For each clinical question, all of the English literature meticulously searched for randomized trials – Large systematic reviews with valid methods + collaborative effort – Conclusions are based on all the evidence from valid randomized trials PDQ (Physician Data Query) mation/pdq/ Clinical Trial Database ? Current Controlled Trials ? NIH PubMed /MEDLINE ? Evidencebased Medicine ? Bases action on best evidence synthesis ? Good doctors use both individual clinical expertise and the best available external evidence, and neither alone is enough. – Without the former, practice
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