味精安全問題ppt課件(完整版)
【正文】 lood. ? 腸道因此能阻止谷氨酸進(jìn)入血液中 ? BloodBrain Barrier prevents GLU peration into brain. ? 血腦屏障阻止谷氨酸滲透到大腦 ? Only very high oral doses of MSG by gavage can raise plasma GLU enough to get GLU into brain ? 只有灌喂大劑量的味精，才會(huì)致血漿中的谷氨酸含量升高，而進(jìn)入到大腦 ? MSG in food does not have this effect. ? 食物中添加的味精不會(huì)有這種效果 Fernstrom JD et al. J Clin Endocrinol Metab 81: 184191, 1996. 1996年，臨床內(nèi)分泌代謝雜志 Adult males (?80 kg) quickly ingested MSG, g (?150 mg/kg) in solution. 成年男子 （體重約 80公斤）能很快吸收溶液中 （約 150毫克每公斤）的味精 Time ( m inu t es)0 60 120 180 240Plasma GLU (nmol/ml)100200300400500Tsai PJ, Huang PC Metabolism 48: 14551460, 1999. Arrows = meal or snack 箭頭代表攝取的食物或點(diǎn)心 Meals: 0745, 1215, 1800 h 飲食時(shí)間： 0745， 1215， 1800 Daily MSG dose = 100 mg/kg: 每日攝入味精量： 100mg/kg Breakfast: 15 mg/kg 早餐： 15mg/kg Lunch: 40 mg/kg 午餐 : 40mg/kg Dinner 45 mg/kg 晚餐： 45mg/kg Data are means 177。 chronic toxicity studies in rats, mice amp。 Physiology, Filer LJ et al., ed. New York, Raven Press, 1979 , pp. 111123. 影響人體母乳二氨基酸濃度的因素 谷氨酸：生物化學(xué)和生理學(xué)進(jìn)展 Brain Issues 大腦問題 ? Relevance to human MSG ingestion: ? 有關(guān)人體攝入味精 ? The placenta blocks GLU transfer from maternal into fetal blood: FETAL brain is safe. ? 胎盤會(huì)阻止谷氨酸從母體傳遞給胎兒：胎兒大腦不會(huì)受到影響 ? Breast milk (GLU) does not rise when mother ingests highdose MSG: NEWBORN/INFANT brain is safe. ? 當(dāng)母體攝入大劑量的味精母乳中的谷氨酸含量不會(huì)上升：新生兒的腦發(fā)育是安全的 ? Infant metabolizes GLU at same rate as adult (Stegink et al., Pediatric Res 20: 5358, 1986). ? 嬰幼兒具有和成年人同樣的谷氨酸代謝的能力 Brain Issues大腦問題 ? The human brain is unaffected by the very high plasma (GLU) following high dose MSG intake ? 攝入大量的味精導(dǎo)致的血漿中高谷氨酸含量不會(huì)對(duì)人體大腦產(chǎn)生影響 ? No dose of MSG has yet been given to humans high enough to induce CNS effects. ? 至今亦未發(fā)現(xiàn)食用味精會(huì)影響人體中樞神經(jīng)系統(tǒng) CRS/Allergy (MSG Symptom Complex) 中國(guó)餐館綜合癥 /過敏癥 味精綜合癥 Studying MSG Symptom Complex 味精綜合癥研究 ? Can reproducible symptoms be defined? ? 能定義這些重復(fù)性的癥狀么？ ? Are reproducible symptoms doserelated? ? 這些重復(fù)性癥狀與攝入劑量有關(guān)嗎 ? ? Do MSGsensitive individuals exist? ? 對(duì)味精敏感的個(gè)體存在嗎？ SYMPTOMS ATTRIBUTED TO MSG:味精所致癥狀 ? Burning, tightness, numbness in upper chest, neck and face. 發(fā)燒，身體發(fā)緊，胸腔上部發(fā)悶，脖子、面部發(fā)麻 ? Dizziness, headache 眩暈，頭疼 ? Chest pain, palpitation 胸口痛，心悸 ? Weakness 乏力 ? Nausea, vomiting 反胃嘔吐 ? Bronchospasm (asthmatics)哮喘 ? Hives (urticaria)麻疹 MECHANISMS UNKNOWN 機(jī)制未知 Multicenter, doubleblind, placebo
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