免疫老化在動(dòng)脈粥樣硬化發(fā)病中的作用(完整版)
【正文】 加被認(rèn)為是機(jī)體免疫老化的表現(xiàn)之一 ,其中斑塊不穩(wěn)定和破裂中發(fā)揮重要作用。79(8 Suppl):154451. Eventfree survival among people (N = 27,939) 免疫因素與粥樣硬化 ? 天然免疫和獲得免疫均參與粥樣硬化的發(fā)生與發(fā)展。81(1):119. Functional Properties of CD4+ T Cells and Their Possible Role in Plaque Rapture Functional properties Possible role in tissue damage Production of large amount of INFγ Activation of tissuedestructive macrophages Defect in CD40 ligand expression Failure to provide help to B cell to produce protective antibodies Cytotoxicity Induction of apoptosis in smooth muscle cells and endothelial cells Autoreactivity Stimulation by selfantigen Defect in apoptosis Longterm cell survival Clonal expansion Occupation of the “space” and outpeting of other imnunopetent cells Expression of HLA class Ⅰ recognizing receptors Tissue migration amplification of cytotoxicity Unique costimulatory molecules Preferential activation in plaque CD4+CD28null T 淋巴細(xì)胞的功能特點(diǎn) CD4+CD28null T 細(xì)胞在 ACS發(fā)病中的作用 Dumitriu IE, Cardiovasc Res. 2020 Jan 1。因此 Kv通道的表達(dá)增加可以做為淋巴細(xì)胞活化的標(biāo)志。 ? 記錄 CD4+CD28nullT細(xì)胞，活化前后 。 結(jié) 果 對(duì)照組 ACS組 ACS患者外周血 CD4+CD28nullT細(xì)胞數(shù)量較對(duì)照組明顯增加 CD4+CD28null T細(xì)胞表面分子的表達(dá) 超過(guò) 70%的 CD4+CD28nullT細(xì)胞為 CCR7CD45RACD45RO+，提示 CD4+CD28nullT細(xì)胞屬于效應(yīng)記憶性 T細(xì)胞 細(xì)胞選擇與封接 應(yīng)用膜片鉗記錄淋巴細(xì)胞 T淋巴細(xì)胞 ACS患者 CD4+CD28null T細(xì)胞活化前后 活化前 活化后 子表達(dá)的影響
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