哈爾濱醫(yī)科大學醫(yī)學微生物學致病性細菌腸道感染病毒(存儲版)
【正文】 ogy, Harbin Medical University Department of Microbiology, Harbin Medical University 腸道病毒特點 ? 生物學性狀 ?小球形病毒（ ~ 30 nm），無包膜 ?核酸為 +ssRNA，有感染性 ?衣殼蛋白 VP1VP3分布在表面， VP4與 RNA結合 ?在胞漿增殖，有明顯 CPE，破胞釋放 ? 耐酸耐乙醚，但鼻病毒除外 ? 引起多種疾病 ?麻痹、無菌性腦膜炎、心肌損傷、腹瀉、皮疹 Department of Microbiology, Harbin Medical University 脊髓灰質(zhì)炎病毒（ Poliovirus） ? First identified in 1909 by inoculation of specimens into monkeys ? First grown in cell culture in 1949 which became the basis for vaccines Department of Microbiology, Harbin Medical University Transmission ? Fecal – oral route (糞－口途徑 ) ?via hands and objects ?via food and water Department of Microbiology, Harbin Medical University Department of Microbiology, Harbin Medical University Department of Microbiology, Harbin Medical University ? The first written record of virus infection ? A heiroglyph from Memphis, drawn in approximately 1400BC, which depicts a temple priest called Siptah showing typical clinical signs of paralytic poliomyelitis Department of Microbiology, Harbin Medical University Franklin D. Roosevelt ? In the summer of 1921, when he was 39, disaster hithe was stricken with poliomyelitis. Demonstrating indomitable courage, he fought to regain the use of his legs, particularly through swimming. Department of Microbiology, Harbin Medical University Manifestations ? Most infections asymptomatic, 95% ? Abortive polio (minor illness), 5% ? fever, malaise, sore throat, myalgia, headache ? Aseptic meningitis (non paralytic polio), 1% ? Paralyt
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