分子診斷學(xué)概論-免費(fèi)閱讀
【正文】 :14:4011:14:40February 12, 2023 1意志堅(jiān)強(qiáng)的人能把世界放在手中像泥塊一樣任意揉捏。 2023年 2月 上午 11時(shí) 14分 :14February 12, 2023 1少年十五二十時(shí)，步行奪得胡馬騎。 2023年 2月 12日星期日 11時(shí) 14分 40秒 11:14:4012 February 2023 1做前，能夠環(huán)視四周；做時(shí)，你只能或者最好沿著以腳為起點(diǎn)的射線向前。 ?遺傳中心法則 DNA→RNA→ 蛋白質(zhì) mRNA的剪切由核內(nèi)的小分子 RNA (snRNA)和 snRNA蛋白質(zhì)複合體 (snRNPs)及 SR蛋白質(zhì)參與，這些分子形成剪接體結(jié)構(gòu)(splicesome) 反轉(zhuǎn)錄酶的發(fā)現(xiàn)顛覆了此中心法則 1970 Howard Termin和 David Baltimore 發(fā)現(xiàn) (1975 Nobel) 一些 RNA病毒能利用反轉(zhuǎn)錄酶將它們的遺傳物質(zhì) (RNA)反轉(zhuǎn)錄為 DNA 靜夜四無鄰，荒居舊業(yè)貧。447(7146):799816 ? The Encyclopedia of DNA Elements (ENCODE) Project provide a more biologically informative representation of the human genome by using highthroughput methods to identify and catalogue the functional elements encoded. ? First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including nonproteincoding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its interrelationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter and intraspecies sequence parisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more prehensive characterization of human genome function. ? The highlights of our findings to date include The human genome is pervasively transcribed, such that the majority of its bases are associated with at least one primary transcript and many transcripts link distal regions to established proteincoding loci. Many novel nonproteincoding transcripts have been identified, with many of these overlapping proteincoding loci and others located
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