疫細(xì)胞bcellppt課件-免費(fèi)閱讀
【正文】 FcγR Ⅱ B傳導(dǎo)抑制信號，下調(diào)體液免疫應(yīng)答。 CK 功 能 IL1 激活淋巴細(xì)胞 IL2 促進(jìn) B細(xì)胞增殖和分泌抗體 IL4 促進(jìn) B細(xì)胞增殖和分化， Ig的類別轉(zhuǎn)換 IL5 介導(dǎo)信號轉(zhuǎn)導(dǎo) IL6 刺激 B細(xì)胞產(chǎn)生抗體 IL7 促進(jìn)淋巴細(xì)胞前體細(xì)胞的增殖和分化 IFNγ 巨噬細(xì)胞活化， MHC抗原表達(dá) Ag CD21 CD81 C3d ss ss CD19 CD79 mIgM CD19/CD21/CD81 信號復(fù)合物 BCR復(fù)合物 （六）補(bǔ)體受體（ CR） （六）補(bǔ)體受體（ CR） B細(xì)胞表面有能與 C3b和 C3d結(jié)合的受體，分別稱為 CRⅠ 和CRⅡ （即 CD35和 CD21）。 B 淋巴細(xì)胞 （ B Lymphocyte, B cell） : The discovery of B cell immunity 1954 Bruce Glick, Ohio State University Studies on the function of the a lymphoid an in the cloacal region of the chicken the bursa of Fabricius Bursectomy – no apparent effect Bursectomised chickens were later used in experiments to raise antibodies to Salmonella antigens None of the bursectomised chickens made antiSalmonella antibodies Bursa was later found to be the an in which antibody producing cells developed – antibody producing cells were thereafter called B cells Mammals do not have a bursa of Fabri
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