c－mycmrna序列-免費閱讀
【正文】 regulation of transcription, DNAdependent /note=p67 myc protein (also called cMyc1)。Connell,P., Leppert,M. and White,R. TITLE Mapping of the MYC gene to band by Rbanding and distal to fra(8)(), FRA8E, by fluorescence in situ hybridization JOURNAL Cytoge. Cell Ge. 57 (23), 109111 (1991) PUBMED 1914517 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from and . On or before Feb 27, 2020 this sequence version replaced gi:113420207, gi:31543215. Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, inframe nonAUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct Ntermini. The synthesis of nonAUG initiated protein is suppressed in Burkitt39。 Eutheria。LOCUS NM_002467 2377 bp mRNA linear PRI 01JUL2020 DEFINITION Homo sapiens vmyc myelocytomatosis viral oncogene homolog (avian) (MYC), mRNA. ACCESSION NM_002467 XM_001129632 VERSION GI:71774082 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota。 Euarchontoglires。s lymphomas, suggesting its importance in the normal function of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1188 636823 1892377 12189 FEATURES Location/Qualifiers source 1..2377 /anism=Homo sapiens /mol_type=mRNA /db_xref=taxon:9606 /chromosome=8 /map= gene 1..2377 /gene=MYC /note=vmyc myelocytomatosis viral oncogene homolog (avian)。 nonAUG (CUG) translation initiation codon。 regulation of transcription from RNA polymerase II promoter [pmid 9924025]。s lymphoma cells. Phosphorylation of cMyc oncoprotein JOURNAL
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