diseaseofhematopoieticandlymphoidsystem-預(yù)覽頁
【正文】 oiesis Accelerated removal or destruction Section two Leukopenia 白細(xì)胞 減少癥 Morphology: hypercellularity marked decrease in maturing granulocytic precursors in the marrow Clinical course Malaise chills and fever followed by marked weakness and fatigability Section two Reactive leukocytosis 反應(yīng)性白細(xì)胞增多癥 mononucleosis lymphadenitis acute nonspecific lymphadenitis chronic nonspecific lymphadenitis disease Section 2 Lymphooid neoplasms Malignant Lymphomas Summary Concept: Lymphomas are malignant tumor which origin from lymph node and other lymphoid tissue. Classification: Two main groups: 1 Hodgkin’s disease(1020%) 2 non Hodgkin’s lymphoma (8090%). Malignant Lymphoma Lymphocytic leukemia Certain important principles must be emphasized % is B Cell origin with Tcell tumors making up most of the remainder tumor of mature B cell arise from and recapitulatethe follicular growth pattern of normal B cells tumors of the immune system, Lymphoid often disrupt normal immune regulatory mechanisms 4. All lymphoid neoplasms are derived from a single transformed cell and are therefore monoclonal. NHLs often present as involvement of a particular tissue site, sensitive molecular assays usuall show that the tumors is widely disseminated at the time of diagnosis. Hodgkin’s Lymphoma(HL) Hodgkin’s Disease (HD) Hodgkin’s disease is disorder involving primarily the lymphoid tissue, the disease, which in the monest type of lymphoma, may occur at any age but there are 2 peaks of incidence ① around adolescence. ② in late middle and older age. Morphology Site: the disease begins in a single lymph node (e. s. cervical) followed by spread to adjacent nodes and to other ans in a fairly consistent pattern. Grossly: single to multiples mass, graywhitecolor,soft,uniform fishflesh . yellowwhite necrosis on the cut surface. Microscopy: 1. The normal architecture of lymph node has been destroyed and replaced by tumour tissue, the variety cells present in the tumour tissue. one constant feature is the presence of Reed Stern berg (RS) cells. ① Typical RS cell large cell: 3060μm dram. Amphophilic cytoplasm large nuclei: two or more nuclei。 彌漫性 彌漫型 中心細(xì)胞性（套細(xì)胞） 單核細(xì)胞樣，包括邊緣帶細(xì)胞 高度惡性 中心母細(xì)胞性 免疫母細(xì)胞性 Burkitt淋巴瘤 大細(xì)胞間變性（ Ki1+） 淋巴母細(xì)胞性 罕見類型 淋巴細(xì)胞性 慢性淋巴細(xì)胞白血病 前淋巴細(xì)胞白血病 小細(xì)胞，腦形 蕈樣霉菌病， Sezary綜合征 淋巴上皮樣 血管免疫母細(xì)胞性 T區(qū)淋巴瘤 多形性，小細(xì)胞性（ HTLV1 177。 ② 非曲核型 免疫表型： TdT(+) SIg() CD10， CD19（ +） 前體 B CD2， CD3， CD7（ +） 前體 T 遺傳特點(diǎn)：多倍體 50個(gè)染色體 t(12:21), t(9:22) t(4:11) 行為：高惡，幾個(gè)月內(nèi)死亡。 有的大小不等呈多形性 。－－－肺－－骨質(zhì)破壞 貧血，反復(fù)感染，不治療迅
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