【正文】
ensity,Images kindly provided by Prof. Segaert,痤瘡樣皮疹,Grade 3 Acnelike rash,推薦治療方法,第十七頁,共二十九頁。,愛必妥持續(xù)(ch237。ngm237。 2) Rothenberg et al, JCO 2003。li225。ngx236。 伊立替康 伊立替康化療(hu224。351:337–345.,第十頁,共二十九頁。 li225。o),0,治療失敗的老鼠(lǎo shǔ)被隨機(jī)分入3組,伊立替康,愛必妥 + 伊立替康,天數(shù),,,,愛必妥,在伊立替康基礎(chǔ)上加用愛必妥能夠逆轉(zhuǎn)伊立替康耐藥(人HT29結(jié)腸癌移植瘤),愛必妥能提高奧沙利鉑的療效并逆轉(zhuǎn)其耐藥(人結(jié)腸癌移植瘤 ),平均腫瘤體積 (mm3),安慰劑,愛必妥,奧沙利鉑,愛必妥+ 奧沙利鉑,天數(shù),0,5,10,15,20,25,30,35,40,45,0,500,1000,1500,2000,2500,3000,,,,Bars: +/ SEM,Prewett M, et al. Clin Cancer Res 2002。o)復(fù)發(fā)轉(zhuǎn)移性結(jié)直腸癌,*Analysis based on IRC assessment. Lenz HJ, et al. Proc Am Soc Clin Oncol. 2005. Abstract 3536 and poster presentation.,第八頁,共二十九頁。,伊立替康治療失敗(shīb224。n n233。ng)細(xì)胞周期進(jìn)程,MYC,MYC,Cyclin D1,FOS,JUN,P,P,Cyclin D1,血管(xu232。 Venook A. Oncologist. 2005。,EGFR阻斷(zǔ du224。 Walker Folprecht et al. ASCO 2004 (Abstract 283).,第二頁,共二十九頁。 Grandis et al. Cancer 1996。i) (非小細(xì)胞肺癌),結(jié)直腸癌,頭頸(t243。HeinzJosef Lenz, M.D. Professor of Medicine and Preventive Medicine University of Southern California/Keck School of Medicine Kenneth Norris Comprehensive Cancer Center Division of Medical Oncology Los Angeles, USA Shanghai, July 2006,抗EGFR單克隆抗體(k224。i 225。351:337–345。19:183–