山東大學(xué)藥理學(xué)研究所-全文預(yù)覽
【正文】 sis of Arrhythmia 1. The electrophysiology of normal 2. cardiac rhythm Section 1 6 7 8 9 2. The electrophysiological mechanism of arrhythmias (1) Disturbances in impulse formation: 1) Increased automaticity: 2) Afterdepolarization and triggered: Early afterdepolarization (EAD) Delayed afterdepolarization (DAD) 10 11 (2) Disturbances in impulse conduction ? 1) Simple conduction disturbances: conduction ↓,conduction block,unidirectional block. ? 2) Reentry (circus movement) (3) Both 12 13 Section 2 The Basic Electrophysilogic Action of Antiarrhythmic Drugs and The Drug Classification 14 1. The basic electrophysilogic action ? 1)↓automaticity a.↓slop of phase 4 depolarization: ↓Na+in or Ca2+in b.↑Threshold potential c.↑maximum diastolic potential: ↑K+out 15 16 17 18 19 2)↓EAD or DAD: ? ↑repolarization, block Na+ or Ca2+ 3)↓reentry: ? a.↑c(diǎn)onduction: unidirectional block↓ ? b.↓conduction : unidirectional block→bidirectional block ? c.↑ERP 20 classification Vaughan Williams（ 1971） ? ClassⅠ Sodium channelblocking agents: IA , IB, IC ? ClassⅡ βblockers ? Class Ⅲ prolonging repolarization ? Class Ⅳ calcium antagonists ? Others: adenosine 21 Section 3 Specific Antiarrhythmic Agents 22 1. ClassⅠ Sodium channelblocking agents 1) ClassⅠ A ? a. Inhibit Na+ influx moderately : ↓Vmax, ↓conduction ↓phase 4 slope, ↓automaticity ? b. ↓ K+ efflux , Increase the ERP 23 Qunidine(奎尼丁 )
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