colven皮膚免疫-全文預(yù)覽
【正文】 immune protection 3. Innate immune defenses 4. Specialized set of APCs 5. Skin homing memory Tcells 6. Antigen presentation in skin 7. Distinct response from other epithelia Cutaneous Immunology Overview I. Brief review of general immunology II. Skin immune system biology III. Skin immune system pathology Contact Dermatitis ? Erythematous, weepy, scaly, geometric plaques ? Irritant or allergeninduced ? Major cause of occupational illness ? Histology: Epidermal spongiosis Allergic Contact Dermatitis Pathogenesis Sensitization (Induction)1o exposure ? Contact allergen usually a hapten – LMW, links with endogenous protein ? Picked up by LC’s and presented to na239。 expression of Eselectin for selective Tcell (CLA +) homing to the skin – expression of VCAM1 amp。ve Tcells – Produce activating cytokines Langerhans’ Cell Migration Antigen From Janeway, CA Immunobiology, 5th ed. Stoitzner, J Inv Dermatol, 2022 Stoitzner, J Inv Dermatol, 2022 Stoitzner, J Inv Dermatol, 2022 Stoitzner, J Inv Dermatol, 2022 Stoitzner, J Inv Dermatol, 2022 Dendritic Cell Maturation: LC FDC ? Phagocytic ? Ag processing ? MHC I, II ? Costimulatory molecules ? Na239。Cutaneous Immunology HuBio 567—The Skin Fall 2022 University of Washington School of Medicine Roy Colven, MD Cutaneous Immunology Summary Points ? The immune system protects us from foreign microinvasion. ? The immune system sometimes screws up. ? The skin has its own immune system. ? Inflammatory skin disorders are understandable. ? New, more specific, treatments emerging. Cutaneous Immunology Overview I. Brief review of general immunology II. Skin immune system biology III. Skin immune system pathology Immunity Innate amp。 toxins – Facilitate humoral immunity – Inhibit Th1 cell proliferation What Determines Th1 vs. Th2 Response? ? Type of pathogen ? Innate immune response to it – Macrophages, NK cells release IL12, IFN? – Mast cells, basophils, ?? T cells release IL4 ? Host’s immune constitution ? Density of Ag presented on APC – High density Th1 – Low density Th2 Cutaneous Immunology Overview I. Brief review of general immunology II. Skin immune system biology III. Skin immune system pathology Inherent (Nonimmune) Skin Defenses ? Physical – Resistance to mechanical trauma – Relatively water impermeable – Physical separation between self and nonself ? Chemical – Free fatty acids – Free radical trapping – Antimicrobial peptides Inherent Skin Defenses (cont’d) ? Photoprotective – Melanin as a UV chromophore ? Injury repair ? Microbiological – Home for colonizing, nonpathogenic bacteria that: ? Compete for nutrients ? Compete for attachment ? Produce antibacterial substances Innate Immune Features of the Skin ? No specialization for skin ? Cells – Phagocytes: Macrophages, neutrophils, NK cells – Mast cells ? Circulating chemicals – Complement ? Locally produced chemicals – Cytokines, histamine Mast Cells ? Bone marrowderived ? Dermal resident ? Perivascular ? Mediators – Preformed (histamine, .) – Newly synthesized (cytokines, .) ? Various stimuli mediator relea
數(shù)學(xué)相關(guān)推薦
鄂ICP備17016276號-1