醫(yī)學(xué)]北大神經(jīng)生物學(xué)課件1-1緒論-全文預(yù)覽
【正文】 min. to hrs Long term memory lasts for weeks De novo 中 國(guó) 神 經(jīng) 科 學(xué) 的 發(fā) 展 開(kāi) 創(chuàng) 者 : 張錫鈞 (協(xié)和 ), 馮德培 (協(xié)和 ,上海生理所 ),張香桐 (上海生 理所 ,腦所 ). 兩大事件 : 視 覺(jué) : 上海 : 生理所 北京 : 生物物理所 EP, EM, Galanin Dynorphin, CCK8 Neural pathways revealed by lesion, stimulation, cfos expression, etc. Arcuate N. hypothalamus Parabrachial N. Chronic Inflammatory Pain （ 炎癥痛） +++ +++ Neuropathic pain （ 神經(jīng)源性痛） +++ + Spinal spastic pain （ 肌痙攣痛） 0 +++ 0 2 8 16 24 48 5d 0 10 20 30 hr control needling 2 Hz 100 Hz n=1112 *** ** * *** *** *** * Time after EA Number of Paw Lifts from cold plate / 5 min The Cumulative Effect of Electroacupuncture on Coldinduced Neuropathic Pain 37 35Hz m 2 15 100 EM / ENK /βEP d ? DYN Antinociception and Treatment of drug addiction Frequency of electroacupuncture Neuropeptides released in CNS Opioid receptors Physiological and therapeutic effects Neurochemical Basis of Acupuncture Effects DREAM Peptide released in CNS Enk Dyn Enk + Dyn A B 2 Hz 2 Hz 100 Hz 100 Hz 3 0 6 9 12 15 s 2 Hz 100 Hz ? Hamza, . et al. (1999) Effect of the frequency of transcutaneous electrical nerve stimulation on the postoperative opioid analgesic requirement and recovery profile. Anesthesiology 91, 12328 ? Wang, . et al. (1997) Effect of the intensity of transcutaneous acupoint electrical stimulation on the postoperative analgesic requirement. Anesth. Analg. 85, 40613 ? Elsayed, A. et al. (1999) Percutaneous electrical nerve stimulation for low back pain. A randomized crossover study. JAMA 281, 818823 ? Hamza, . et al. (1999) Effect of the duration of electrical stimulation on the analgesic response in patients with low back pain. Anesthesiology 91, 16227 ? Hamza, ., et al. (2022) Percutaneous electrical nerve stimulation: a novel analgesic therapy for diabetic neuropathic pain. Diabetic Care 23, 365370 實(shí)驗(yàn)研究結(jié)果的 臨床驗(yàn)證 Clinical verification of basic research 11 Nerve pathways for low and high frequency EA analgesia 100 Hz 2 Hz ?end Enk Dyn PBN Arcuate N. Hypoth. PAG Medulla DHN 0 25 50 75 100 125 150 2 . 50 . 02 . 55 . 07 . 5T i m e ( s )Signal Intensity (%)R. Primary Motor Area (RMI) R. Supplementary Motor Area (RSMA) 0 20 40 60 80 100 120 2 . 50 . 02 . 55 . 07 . 5T i m e ( s )Signal Intensity (%) 0 25 50 75 100 1250 . 0 00 . 2 50 . 5 00 . 7 51 . 0 0p 0 . 0 0 1% c h a n g e o f p a i n t h r e s h o ld ( r a d i a n th e a t w i t h d r a w a l)Correlation Coefficient0 25 50 75 100 1250 . 0 00 . 2 50 . 5 00 . 7 5p 0 . 0 1% c h a n g e o f p a i n t h r e s h o ld ( r a d i a n th e a t w i t h d r a w a l)Correlation Coefficient Brain areas involved in AA: fMRI studies in humans Positive correlation 43 41 R. Hippocampus (RHi) L. Hippocampus (LHi) 0 20 40 60 80 100 120 2 . 50 . 02 . 55 . 07 . 5T i m e ( s )Signal Intensity (%)0 20 40 60 80 100 120 2 . 50 . 02 . 55 . 07 . 5T im e ( s )Signal Intensity (%)0 25 50 75 100 125 0 . 7 5 0 . 5 0 0 . 2 50 . 0 0p 0 . 0 1% c h a n g e o f p a i n t h r e s h o ld ( r a d i a n th e a t w i t h d r a w a l)Correlation Coefficient0 25 50 75 100 125 0 . 7 5 0 . 5 0 0 .
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