proteinkinasecanditsinvolvementinpathophysiologicdisorders-全文預(yù)覽
【正文】 ath. Stroke. 20xx。44:105–109) ? cPKC? is activated specifically during reperfusion. (J Cereb Blood Flow Metab. 20xx。 47:136 –145) Email: ?Preconditioning stimuli, including hypoxia, lead to a decrease in cellular ATP stores and the subsequent generation of adenosine, A1/A3 adenosine receptors (ARs) activate PLC via Gproteins. Stroke. 20xx。 Cerebral Ischemia/ Reperfusion Injury PKC Involved in Pathophysiologic Disorders Email: ?Ischemic core ? Distal to an occluded artery, undergoes rapid, anoxic cell death within minutes. ? Irreversible processes: mitochondrial collapse, rapid energy depletion, and ion pump failure result in large increases in intracellular calcium, extracellular potassium, and edematous cell swelling, characteristic of necrotic cell death ?Ischemic penumbra ? Metabolism and intracellular signaling cascades are maintained partly by hypoperfusion from a diminished collateral blood supply. ? Affected by multiple stresses: regional glutamate, potassium diffusion and periinfarct depolarizations emanating from the ischemic core. Email: Email: ?Ischemic Tolerance: Role of nPKC? ? Sustained activation of nPKC? after OGD. (Neuropharmacology 20xx。 20: 63396347 Binding of pseudoRACK peptide (step 2b), to the enzyme in this transient form may stabilize it, and leave the RACKbinding site exposed. Email: ?Peptide Translocation Activators of Specific PKC Isozymes Current Pharmaceutical Design 20xx。 RACK: Receptor for activated C Kinase Current Pharmaceutical Design 20xx。 55: 461–466. Email: ?A schematic sequence of PKC isozymes indicating the regulatory and catalytic (protein kinase) domains Current Pharmaceutical Design 20xx。 diabetic retinopathy Email: ? A cyclic nucleotideindependent, proteolytically modified protein kinase from mammalian brain. (J Biol Chem 1977。 Basal ganglia diseases 6. PKC amp。 Protein Kinase C and Its Involvement in Pathophysiologic Disorders Junfa Li, . Department of Neurobiology Capital Medical University Email: 1. General information of PKC 2. PKC amp。 Alzheimer’s disease 5. PKC amp。 Cancer 9. PKC amp。 1450: 99–106) ? Discovery of protein kinase C (PKC) Email: ?Mammalian protein kinase C isoenzymes: (造血組織 ) PKCm, n PKD1, PKD3 Email: Chronological studies on PKC Pharmacological Research 20xx。 370: 361–371. Email: RICK: Receptor for inactivated C Kinase。 20: 63396347 ? Inhibitors and activators of binding of an enzyme to its adaptor can be rationally designed PseudoRACK peptides, are derived from a sequence in PKC that shares homology with its corresponding RACK. However, there is a charge difference between the pseudoRACK sequence and the corresponding sequence of the PKCbinding site on RACK. Email: Oncogene 20xx。 11: 549559 Email: PKC amp。 47:136 –145) ? The protective effect of the nPKC? activator was lost when delivered after OGD in these models. (Neuropharmacology. 20xx。36:27812790. Email: ?Ischemia and the Role of Neuronal cPKC? cPKC? may play a deleterious role during early isc
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