【正文】 1月出生于英國柴郡的一個 牧師家庭，1898年卒于薩里。如果說劉易斯故事簡介Alice, sitting with her sister, is White Rabbit scurries by, muttering to himself and pulling a watch from his waistcoat , Alice follows the animal down a rabbit hole, the first of many instances in which she is propelled by her falls, landing in a pile of finds herself in a hall and discovers a tiny key to a tiny door leading to a drinks from a bottle labeled DRINK ME, 。至少他的兩部《愛麗絲》一改此前傳統(tǒng)童話（包括《安徒生童話》、《格林童話》）充斥著殺戮和說教的風格，從而奠定了怪誕、奇幻的現(xiàn)代童話基調(diào)。他的第一本童書《愛麗絲奇境歷險記》于1865年出版，當時就引起了巨大轟動，1871年又推出了續(xù)篇《愛麗絲穿鏡奇幻記》，更是好評如潮。路德維?？_爾（Lewis Carroll），原名查爾斯小姑娘從自己所處的棋格開始，一步一步向前走，每一步棋都有奇妙的遭遇：愛麗絲會腳不沾地地飛著走路，那里的花朵和昆蟲都會說話，白王后變成了綿羊女店主，她手中的編織針變成劃船的槳，等等。兔子洞里還另有乾坤，她在一扇小門后的大花園里遇到了一整副的撲克牌，牌里粗暴的紅桃王后、老好人紅桃國王和神氣活現(xiàn)的紅桃杰克（J）等等。?guezUbis, ., 2002, 1, , , , , and , ., 2010, 26, , , and , ., 2008, 130, and , ., 1981, 14, , , , , , and , ., 2005, 44, , , and , ., 1999, 99, , , , , and , ., 2000, 39, , , , and , , 1991, 9, , ., 2000, 205, , , and , ., 1998, , , , , , , , , , and , ., 2000, 122, , , , , , , , , , and , ., 2002, 124, 12697– and , ., 1981, 14, and , ., 1982, 54, , ., 2009, 109, , , , , , and , ., 2005, 44, journal is 169。onRodr180。oth, Future ., 2010, 2, , , and , ., 2000, 205, , , , , and , ., 1999, , , , , , and Sousa, New ., 1998, 22, and , ., 2000, , , , and Sousa, ., 1997, 119, , , and , ., 2006, 128, , , , , , , and , ., 2001, 123, , , and , ., Perkin , 2001, 180。180。the number of coordinated water molecules(q)decreased from to features Luminescence lifetime experiments were performed to explore the mechanism of the Cu2+triggered relaxivity lifetime measurements of lanthanide plexes have been widely used to quantify the number of innersphere water In particular, Tb3+ and Eu3+ have monly been applied for lifetime measurements because their emission spectra are in the visible region when their 4f electrons are relaxed from higher energy levels to the lowest energy ,73 Therefore, the Tb3+ analogue of [Gd2(DO3A)2BMPNA], [Tb2(DO3A)2BMPNA], was prepared according to a similar method, and the luminescence lifetimes of the Tb3+ analogue in HEPESbuffered H2O and D2O in the absence and presence of Cu2+ were shown in ,? the luminescence decay curve of [Tb2(DO3A)2BMPNA] was tted to obtain the luminescence lifetimes74(Table 1), and the number of coordinated water molecules(q)was calculated by eqn(2).The analysis results(Table 1)for [Tb2(DO3A)2BMPNA] in HEPESbufferedH2OandD2O in the absence and presence of Cu2+ indicated that q increased from to upon the addition of 1 Cu2+。and number of acquisitions = and discussion Longitudinal relaxivity of [Gd2(DO3A)2BMPNA] in response to copper(II)ion To investigate the inuence of Cu2+ on the relaxivity of [Gd2(DO3A)2BMPNA], the longitudinal relaxivity r1 for the [Gd2(DO3A)2BMPNA] contrast agent was determined using T1 measurements in the absence or presence of Cu2+ at 60 MHz and 25 C using a + solution of [Gd2(DO3A)2BMPNA] in 100 mM HEPES buffer(pH )under simulated physiological concentrations of Gd3+ were determined by relaxivity r1 was calculated from eqn(1).In the absence of Cu2+, the relaxivity of [Gd2(DO3A)2BMPNA] was mM1 s1, which was higher than that of [Gd(DOTA)(H2O)]( mM1 s1, 20 MHz, 25 C)and Gd(DO3A)(H2O)2( mM1 s1, 20 MHz, 40 C).64 Upon addition of up to 1 Cu2+, the relaxivity of [Gd2(DO3A)2BMPNA] increased to mM1 s1(76% relaxivity enhancement).As shown in , the relaxivity gradually increased with the copper ion concentration, reaching a maximum value of approximately equivalents of Cu2+.Due to the use of triuoroacetic acid in the synthesis of Compound 4, triuoroacetic acid residues produced CF3COO in the [Gd2(DO3A)2BMPNA] solution, allowing CF3COO to partially coordinate with Cu2+ to form “Chinese lantern” type structure When the amount of added copper ions was further increased to above equiv., the relaxivity was maintained at the same observed difference in Cu2+triggered relaxivity enhancement demonstrated the ability of this contrast agent to sense Cu2+ in vivo by means of designed contrast agent not only exhibited a higher relaxivity, but also displayed a Cu2+responsive relaxivity studies The relaxivity response of [Gd2(DO3A)2BMPNA] exhibited excellent selectivity for Cu2+ over a variety of other peting, biologicallyrelevant metal ions at physiological depicted in (white bars), the addition of alkali metal cations(10 mM Na+, 2 mM K+)and alkaline earth metal cations(2 mM Mg2+, 2 mM Ca2+)did not generate an increase in relaxivity pared to the copper ion turnon response。matrix =256 256。(1/T1)d + r1[M](1)where(1/T1)obs and(1/T1)d are the observed values in the presence and absence of the paramagnetic species, respectively, and [M] is the concentration of paramagnetic [Gd].Luminescence emission spectra were collected on a Hitachi uorescence luminescence lifetime was measured on a Lecroy Wave Runner 6100 Digital Oscilloscope(1 GHz)using a tunable laser(pulse width 188。N, 。emission slit, 10 luminescence lifetime was measured on a Lecroy Wave Runner 6100 Digital Oscilloscope(1 GHz)using a tunable laser(pulse width 188。dela time, ms。s metabolism and function more and more effective and agents are often used in MRI examinations to improve the resolution and sensitivity。in the absence of Cu2+, the plex exhibited a relatively low relaxivity value( mM1 s1), while the addition of Cu2+ triggered an approximately 76% enhancement in relaxivity( mM1 s1).Moreover, this Cu2+responsive contrast agent was highly selective in its response to Cu2+ over other biologicallyrelevant metal influence of some mon biological anions on the Cu2+responsive contrast agent and the luminescence lifetime of the plex were also results of the luminescence lifetime measurements indicated that the enhancement in relaxivity was mainly ascribed to the increased number of innersphere water molecules binding to the paramagnetic Gd3+ core upon the addition of Cu2+.In addition, the visual change associate