器官移植的發(fā)展與未來(文件)
【正文】 r the operation. The Brigham mando : 1947 ? A young woman was in profound a with anuria for 10 days following an abortion plicated by acute tubulopathy due to septic shock and inpatible transfusion. David M. Hume (19171973) Paris, Christmas 1952 : the present from a mother to her son Mrs Renard and her son Marius to whom she donated a kidney in December 1952. Pelvic implantation of the kidney with restoration of the urinary tract. A real Success : 1954 John Merrill and Joseph Murry (Nobel Prize 1991) at the Brigham in 1953 First susccessful transplantation between two identical twins in 1954 by the Murry, Merrill and Harrison team. Peter Brian Medawar, Nobel Prize in 1960. Rejection was by the action of lymphocytes which described as “ immunoeptent cells “ MAJOR HISTOCOMPATIBILITY COMPLEX : 1952 ( Jean Dausset, Nobel Prize in 1980 ) ( Human MHC ) Immunosuppression : Total Body Irradiation “ Sam” and “ Honest John” First prolonged survival of renal transplantation with an unrelated donor Mrs Gen and her donor at Foch Hospital in 1960 Development of Immunosuppressive Drugs Marianne Mattlaer with “ Mana” , who received a kidney in 1960 with immunosuppression by azathioprine, with a litter tow years after the transplantation. Advent of Cyclosporine The primitive fungus from which cyclosporine is extracted (Tolypocladium inflatum) Sir Roy Calne Progress in Hemodialysis William J. Kolff, father of the artificial kidney
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