【正文】
ed Derwent Reg.(顯示連鎖遺傳的德溫特登記號(hào)) DS DS KW Designated States (Regional)(EP指定國(guó)) EPAB BI TEXT EP Equivalent Abstract(EP相同專利文摘) FS FS KW File Segment(德溫特領(lǐng)域) GBAB BI TEXT GB Equivalent Abstract(GB相同專利文摘) IC IC KW IPC Issuing Office(IPC號(hào)) IKW BI TEXT Index Words(標(biāo)引詞) IN IN KW Inventor Name(發(fā)明人姓名) INW IN TEXT Inventor Name(發(fā)明人姓名) IW BI KW Index Words(標(biāo)引詞) KS KS KW Plasdoc Key Serials(塑料代碼主序號(hào)) MC MC KW Manual Codes(手工代碼) M0M6 M0 KW Chemical Codes(化學(xué)代碼) NC NC ONUM Number of Countries(國(guó)家代碼) OPD OPD ODAT Oldest Priority Date(最早優(yōu)先日) ORD ORD ODAT Oldest Reference Date(最早參考日) PA PA KW Applicant Name(申請(qǐng)人姓名) PAW PA TEXT Applicant Name(申請(qǐng)人姓名) PN PN KW Publication Number(申請(qǐng)?zhí)枺? PR PR KW Priority Data(優(yōu)先項(xiàng)) RR RR KW Ring Index Numbers(環(huán)系索引代碼) RRL RR KW Linked ring (顯示連鎖遺傳的環(huán)系索引代碼) TI BI TEXT Title(標(biāo)題) USAB BI TEXT US Equivalent Abstract(美國(guó)相同專利文摘) XA XA KW Secondary Accession Number (CPI)(第二入藏登記號(hào)) XIC XIC KW CrossSearching IC(交叉檢索用IPC號(hào)) XP XP KW Secondary Accession Number (NONCPI)(非化學(xué)第二入藏登記號(hào)) XR XR KW Related Accession Numbers(相關(guān)入藏登記號(hào)) 下面是一條DWPI中的記錄,上表中所列的字段并不一定全部出現(xiàn): AN 1999510743 [43] (德溫特入藏登記號(hào)) XA C1999149416 (第二入藏登記號(hào)) DC A28 A96 B05 B06 B07 (德溫特分類號(hào)) FS CPI (德溫特領(lǐng)域) PA (LIPH ) LIPHA LYONNAISE IND PHARM (MERE ) MERCK PATENT GMBH (專利權(quán)人) IN GIET P; HULOT T; MICHEL D; SASLAWSKI O (發(fā)明人) PN FR2775188 A1 19990827 DW199943 A61K47/36 058pp (專利號(hào)) WO9942086 A1 19990826 DW199943 A61K9/16 Eng 000pp DS BE CY EA FR GR IE IT MC NL OA SZ (EP指定國(guó)) PR FR19980002143 19980223 (優(yōu)先項(xiàng)) IC A61K9/16 。 A61K9/52 。 A61K47/26 。 P0055 。 M9999 M2186 (塑料代碼)(以下略) M1 [03] H4 H402 H482 H5 H589 H8 M280 M312 M323 M332 M342 M383 M393 M423 M431 M510 M520 M530 M540 M620 M782 M904 M905 M910 Q120 R031。 A61K009/20 。 A61K031/155 。 A61K047/36 (交叉檢索用IPC號(hào)) IW ORAL COMPOSITION IMPROVE ABSORB GASTRO TRACT CONTAIN ABSORB PROMOTE BALANCE (標(biāo)引詞) AB FR2775188 NOVELTY Medicaments for oral administration having hydrophilic or ionizable active ingredients, an absorption promoter having an HLB (hydrophilelipophile balance) of over 8 that is a lipidic material. (新穎性) DETAILED DESCRIPTION The lipidic material is selected from one or more of the following: polysorbates, alkylethers, polyoxyethylene ethers, fatty acid polyoxyethylene esters, fatty acids, fatty alcohols, biliary acids and their salts, 16C alkanol esters with fatty acids, fatty acid 26 OH polyol esters, and polyglycosylated glycerides, in association with one or more pharmaceutical excipients, except for pharmaceutical forms containing captopril. The active material is preferably calcium acamprosate, metformin or metformin hydrochloride. The positions preferably contain 10 % by weight of the absorption promoter, especially 2 %. The positions may further contain an agent to control the kinetic liberation of the active material, especially glycerol palmostearates, glycerol behenates, hydrogenated castor oil, and their mixtures. (發(fā)明詳述) ACTIVITY The bioavailability of calcium acetylhomotaurinate (calcium acamprosate) was determined in beagle dogs using various formulations containing 333 mg of active material. For control purposes, a standard coated tablet formulation was used. Compositions of the invention contained 1 % soya lecithin, or 34 % lactose, together with Gelucire 44/