免疫調(diào)節(jié)碩ppt課件-wenkub
2023-04-06 01:55:15 本頁(yè)面
【正文】 secreting (Th3) ? ? CD8+ CD28 ? ? γδ T cells ? ? NK T cells How are Tregs induced? ? Some arise naturally as a distinct population (., nTreg and NK T cells) ? Others are induced as a result of antigen exposure in a permissive cytokine environment (., aTreg and Tr1 cells) ? Multiple subsets reflect the importance of maintaining immune homeostasis and self tolerance under many different circumstances How do regulatory T cells work? Contact CD4+ CD25+ regulatory T cells MHC II TCR Adapted from: Wood, . and Sakaguchi, S. (2022) Nat Rev Immunol 3, 199210 Conventional T cell Treg: Suppress the outgrowth of potentially pathogenic selfreactive T cells (conventional T cells) ? Prevention and treatment of immunemediated disease ? Control of autoimmunity ? Contribute to cancer development CD4+ CD25+ regulatory T cells ? Nishizuka 和 Sakakura 在 1969 年曾經(jīng)報(bào)道 ,出生后第 3 天切除胸腺將導(dǎo)致小鼠發(fā)生自身免疫病 ,而出生第 1 天或者 7 天后切除胸腺則沒有類似現(xiàn)象發(fā)生。 ? 如今看來這些調(diào)節(jié)性 T細(xì)胞很可能就是 CD4+ CD25+ T 細(xì)胞，人們今天對(duì) CD4+ CD25+ Tr 細(xì)胞的認(rèn)識(shí)較幾十年前的 Ts 細(xì)胞要深刻、成熟得多 ? Sakaguchi 等人于 1995 年發(fā)現(xiàn) ,未免疫 (naive) 小外周循環(huán)中的 CD4 + T 細(xì)胞約 10 %表達(dá)CD25 （ IL－ 2 受體 α鏈 ) 。ve T cells in the presence of IL10 ? ? Cytokine profile is ? – high IL10, TGFβ, IL5 ? – low IFNγ, IL2 ? – no IL4 ? ? Can be CD4 or CD8 ? ? Proliferate poorly ? ? Migrate to inflamed tissues ? ? Immune suppression through cytokines, not contact ? ? IL10 polymorphisms that alter
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