安捷倫6410液質(zhì)聯(lián)用資料newerainlc-msquantitativeanalysis(agilentmasshunterworkstation)-wenkub
2023-03-08 14:54:31 本頁面
【正文】 Era in LC/MS Quantitation Agilent Restricted May 31, 2022 Page 1 New Era in LC/MS Quantitative Analysis Agilent 6410 Triple Quad LC/MS Agilent MassHunter Workstation Agilent Technologies, Inc. Life Sciences and Chemical Analysis Frank Kuhlmann Senior Scientist LC/MS Software Development ASMS 2022, 31May2022 New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 2 Program Agilent 6410 Q Hardware – 10 min. ? Performance, Reliability, EaseofUse, Cost of Ownership Agilent MassHunter Workstation Software – 30 min. ? Fast Learning Curve, EaseofUse, Productivity, Reporting ? Acquisition Software ? Quantitative Analysis Software Features Life Demos ? BatchAtA Glance User Interface and Navigation ? Quant Method Editor ? Outlier Flagging and Filtering on over 20 Parameters ? Parameterless MSMS Integrator w/ builtin peak validation ? Curve Fit Assistant and other Productivity Tools ? Powerful reporting based on Excel 2022 Pro and XML Life Demo Future ? 21CFRPart 11 Compliance ? Automated MRM Acquisition Method Development ? Support of all Agilent MS instrumentation (LC/MS, GC/MS, ICP/MS) Questions + = New Era in LC/MS Quantitative Analysis New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 3 Program Agilent 6410 Q Hardware – 10 min. ? Performance, Reliability, EaseofUse, Cost of Ownership Agilent MassHunter Workstation Software – 30 min. ? Fast Learning Curve, EaseofUse, Productivity, Reporting ? Acquisition Software ? Quantitative Analysis Software Features Life Demos ? BatchAtA Glance User Interface and Navigation ? Quant Method Editor ? Outlier Flagging and Filtering on over 20 Parameters ? Parameterless MSMS Integrator w/ builtin peak validation ? Curve Fit Assistant and other Productivity Tools ? Powerful reporting based on Excel 2022 Pro and XML Life Demo Future ? 21CFRPart 11 Compliance ? Automated MRM Acquisition Method Development ? Support of all Agilent MS instrumentation (LC/MS, GC/MS, ICP/MS) Questions + = New Era in LC/MS Quantitative Analysis New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 4 ? For food safety, environmental, chemical, forensics, pharmaceutical and metabolomics markets ? High analytical performance ? Reliability ? Ease of use ? Low cost of ownership What are the biggest issues which customers face in Q LC/MS/MS Quantitation HARDWARE Design Objectives for the 6410 Triple Quad LC/MS New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 5 Performance – Bentazon Herbicide 100 fg LOQ Femtogram sensitivity with excellent reproducibility RSD % Resp. Factor 1512 RSD % Resp. Factor 1546 RSD % Resp. Factor 1542 RSD % Resp. Factor 1526 RSD % Resp. Factor 1009 100 fg 1 pg 10 pg 100 pg 1 ng MRM Parameters: 3 transitions 100msec dwell/transition 315msec cycle time (precursor ion) (quantifier ion) (qualifier ion) New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 6 Performance – Reserpine in Coffee 160 fg LOQ 20pg 10pg 5pg Blank Blank New Era in LC/MS QuantAnalysis Agilent Restricted May 31, 2022 Page 7 Reliability Agilent 6410 Triple Quad LC/MS ? Patented Orthogonal Ion Source Designs ? Superio
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