n蛋白質(zhì)合成ppt課件-wenkub
2023-01-29 07:25:45 本頁面
【正文】 . tRNA structure. (a) Cloverleaf structure showing the invariant and semivariant nucleotides, where I = inosine, Ψ = pseudouridine, R = purine, Y = pyrimidine and * indicates a modification. (b) Tertiary hydrogen bonds between the nucleotides in tRNA are shown as dashed lines. (c) The Lshaped tertiary structure of yeast tRNATyr. Part (c) reproduced from . Freifelder (1987) Molecular Biology, 2nd Edn. tRNA structure Molecular Biology tRNA的功能 解讀 mRNA的遺傳信息 運輸?shù)墓ぞ?，運載氨基酸 tRNA有兩個關(guān)鍵部位： ● 3’端 CCA：接受氨基酸，形成氨酰 tRNA。 Fig. 4. Identity elements in various tRNA molecules. The synthetases have to be able to distinguish between about 40 similarly shaped, but different, tRNA molecules in cells, and they use particular parts of the tRNA molecules, called identity elements, to be able to do this. ? 氨基酸的活化 ? 翻譯的起始 ? 肽鏈的延伸 ? 肽鏈的終止 ? 蛋白質(zhì)前體的加工 Q 蛋白質(zhì)合成 表 147 原核和真核生物核糖體的組成及功能 核糖體亞基 rRNAs 蛋白 RNA的特異順序和功能 細菌 70S 50S 23S=2904b 31種 (L1L31） 含 CGAAC和 GTψCG互補 106D 5S=120b 66%RNA 30S 16S=1542b 21種 (S1S21) 16SRNA(CCUCCU)和 SD 順序 (AGGAGG)互補 哺乳動物 80S 60S 28S=4718b 49種 有 GAUC和 tRNAfMat的 TψCG互補 106D 5S=120b 60%RNA =160b 40S 18S=1874b
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