山東大學(xué)藥理學(xué)研究所(已修改)
2025-01-04 05:14 本頁面
【正文】 CHAPTER 22 ANTIARRHYTHMIC DRUGS 醫(yī)學(xué)院藥理學(xué)研究所 丁華 1 2 Arrhythmia: ? There is an abnormality in the site of origin of the impulse, its rate or regularity , or its conduction . 3 4 The type of Arrhythmia: 緩慢型 : 竇性心動過緩 (sinus bradycardia) 房室傳導(dǎo)阻滯 (atrioventricular block) 快速型 : 房性早搏 (atrial premature contraction) 房性心動過速 (atrial tachycardia,AT) 心房顫動 (atrial fibrillation, AF) 心房撲動 (atrial flutter, AFL) 陣發(fā)性室上性心動過速 ( p a r o x y s m a l s u p r a v e n t r i c u l a r tachycardia) 室性早搏 ( v e n t r i c u l a r p r e m a t u r e contraction) 室性心動過速 (ventricular tachycardia,VT) 心室顫動 (ventricular fibrillation, VF) 5 The Physiological Basis of Arrhythmia 1. The electrophysiology of normal 2. cardiac rhythm Section 1 6 7 8 9 2. The electrophysiological mechanism of arrhythmias (1) Disturbances in impulse formation: 1) Increased automaticity: 2) Afterdepolarization and triggered: Early afterdepolarization (EAD) Delayed afterdepolarization (DAD) 10 11 (2) Disturbances in impulse conduction ? 1) Simple conduction disturbances: conduction ↓,conduction block,unidirectional block. ? 2) Reentry (circus movement) (3) Both 12 13 Section 2 The Basic Electrophysilogic Action of Antiarrhythmic Drugs and The Drug Classification 14 1. The basic electrophysilogic action ? 1)↓automaticity a.↓slop of phase 4 depolarization: ↓Na+in or Ca2+in b.↑Threshold potential c.↑maximum diastolic potentia
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