呼吸系統(tǒng)疾病-豬肺炎支原體(已修改)
2025-06-07 05:36 本頁面
【正文】 Respiratory Disease – Mycoplasma hyopneumoniae 呼吸系統(tǒng)疾病－豬肺炎支原體 Bob Morrison DVM, MBA, PhD Swine Group University of Minnesota 明尼蘇達(dá)大學(xué) Mycoplasma hyopneumoniae 豬肺炎支原體 ? Transmission is primarily by direct contact with carrier swine. 傳播的主要途徑是與病原攜帶豬的直接接觸。 ? Airborne transmission possible 經(jīng)呼吸道傳播使感染成為可能 ? Any age pig is susceptible to infection. 所有日齡的豬都易感。 ? Maintained in herds by sow (primarily parity 1,2) to suckling pig contact. 在豬群中通過母豬（主要是第一、二產(chǎn)次母豬）與哺乳仔豬 接觸導(dǎo)致其持續(xù)存在。 ? Primary clinical problem is in growing pigs, 3 to 6 months old 主要臨床問題出現(xiàn)在 3到 6月齡的生長(zhǎng)豬群身上 Mycoplasma hyopneumoniae 豬肺炎支原體 ? Long incubation period – 10 to 16 weeks 長(zhǎng)潛伏期－ 1016周 ? Slow spread 緩慢傳播 ? Large numbers present in the early stages of disease 大量的病例出現(xiàn)于疾病的早期階段。 ? Disease onset is gradual – coughing for weeks to months 疾病的發(fā)病是漸進(jìn)性的 ——咳嗽可持續(xù)數(shù)周到數(shù)月 ? Disease course is markedly affected by concurrent or secondary infections 疾病的進(jìn)程明顯受并發(fā)或繼發(fā)感染的影響 ? High variation in virulence 病原毒力差異很大 What does do? 豬肺炎支原體有什么影響？ ? Colonizes tracheal epithelium 病原定居于氣管上皮細(xì)胞 ? Destroys cilia in tracheobronchi, interferes with clearance mechanisms 摧毀氣管、支氣管上皮的纖毛，干擾氣管的清除機(jī)制 ? Interferes with macrophage activity 干擾了巨噬細(xì)胞活性 ? Mononuclear peribronchial infiltration 單核細(xì)胞在支氣管周圍浸潤(rùn) ? Produces lesions of pneumonia 造成肺炎的病變 ? May be severe in susceptible animals 對(duì)易感動(dòng)物可能有嚴(yán)重后果 ? Produces slight ? ADG 導(dǎo)致豬平均日增重的輕微下降 ? Allows bacterial superinfections Pasteurella, Strep, Actinobacillus 易發(fā)生細(xì)菌的雙重感染 ——巴氏桿菌、鏈球菌、放線菌 Immunohistochemical stain 免疫組化染色 Diagnosis
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