dnadamage-inducedphosphorylationofmdmxatserine367：在dna損傷誘導(dǎo)的磷酸化絲氨酸367的mdmx(已修改)
2025-01-24 07:52 本頁面
【正文】 DNA DamageInduced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2Dependent Degradation MOLECULAR AND CELLULAR BIOLOGY, Nov. 2022, p. 9608–9620 Mdmx interacts with 1433 proteins while Mdm2 does not 1433 binding is abolished by S367A substitution Mdmx S367 is phosphorylated in vivo According to the author, this data also indicates that 1433 proteins require a phosphorylated serine site in order to bind Mdmx consistent with previous findings related to 1433 binding consensus sequences. a Flag a PS367 IP: Flag lphosphatase + Supplementary figure indicating specificity of the
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