《藥理學(xué)》第6章膽堿受體激動(dòng)藥-文庫(kù)吧
2025-07-10 22:12 本頁(yè)面
【正文】 酰膽堿 (acetylcholine, ACh) – 減慢心率 – 減慢房室結(jié)和浦肯野纖維傳導(dǎo) – 減弱心肌收縮力 – 縮短心房不應(yīng)期 竇房結(jié)舒張期自動(dòng)除極延緩 →動(dòng)作電位到達(dá)閾值時(shí)間 ↑ 不應(yīng)期 ↑→傳導(dǎo) ↓ 迷走神經(jīng)釋放 Ach→激動(dòng)交感神經(jīng)末梢突觸前M受體 →反饋性抑制交感神經(jīng)末梢釋放 NE→心肌收縮力 ↓ 心房不應(yīng)期 ↓ 動(dòng)作電位時(shí)程 ↓ Blood vessels arteries dilation (via EDRF) constriction (highdose direct effect) Heart sinoatrial node decrease in rate (negative chronotropy) atria decrease in contractile strength (negative inotropy) decrease in refractory period atrioventricular node decrease in conduction velocity (negative dromotropy). increase in refractory period ventricles small decrease in contractile strength 乙酰膽堿 (acetylcholine, ACh) 胃腸道 泌尿道 其他 – 腺體 – 眼 – 神經(jīng)節(jié)和骨骼肌 – 中樞 – 支氣管 乙酰膽堿 (acetylcholine, A
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