考研資料北京大學(xué)細(xì)胞生物學(xué)第六章基質(zhì)與內(nèi)膜(上)-文庫(kù)吧
2024-12-23 15:24 本頁(yè)面
【正文】 of total cell volume Cytosol 54 Mittchondria 22 Rough ER cisternae 9 Smooth ER cisternae plus Golgi cisternae 6 Nucleus 6 Peroxisome 1 Lysosomes 1 Endosomes 1 Relative volumes occupied by the major intracellular partments in Liver Cell C. The Dynamic Nature of the Endomembrane System ?Most anelles are part of a dynamic system in which vesicles move between partments. ?Biosynthetic parthways move proteins, carbohydrates and lipids within the cell. ?Secretory pathways discharge proteins from cells. ?Endocytic parthways move materials into cells. ?Sorting signals are recognized by receptors and target proteins to specific sites. D. A few approaches to the study of cytomembranes ? Insights gained from autoradiography。 ? Insights gained from the biochemical analysis of subcellular fractions。 ?Insights gained from the study of geic mutants。 The dynamic activities of endomembrane systems are highly conserved despite the structural diversity of different cell types. De Duve, and ,1974 Nobel Plrize 2. The structure and functions of Endoplasmic Reticulum(ER) Rough endoplasmic reticulum and Smooth endoplasmic reticulum RER has ribosomes on the cytosolic side of continuous, flattened sacs(cisternae)。 SER is an interconnecting work of tubular membrane elements. Microsome(100200nm) rER of pancreatic cells Microsomes are heterogeneous mixtures of similarsized vesicles, formed from membranes of the ER and Golgi plex. Microsomes retain activity during purification, allowing studies of function and position. A. Functions
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