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Sedative and anxiolytic effects of zopiclone39。因此，本文通過(guò)對(duì)植物原料中吡咯里西啶類生物堿的提取，進(jìn)而探索該類生物堿催化不對(duì)稱有機(jī)反應(yīng)的催化性能。吡咯里西啶生物堿在自然界大量存在,來(lái)源較廣，結(jié)構(gòu)類型多，有400多種，含有多個(gè)立體中心和官能團(tuán)，從中尋找適合于某些不對(duì)稱有機(jī)反應(yīng)的有機(jī)小分子催化劑具有可行性。目前所采用的不對(duì)稱有機(jī)小分子催化劑的種類仍然十分稀少，大多數(shù)不對(duì)稱有機(jī)小分子催化劑即使通過(guò)結(jié)構(gòu)修飾也只能催化一些機(jī)理類似的少數(shù)幾種反應(yīng)。因此對(duì)手性有機(jī)小分子催化劑的研究越來(lái)越多地受到人們的重視。例如它們可以催化不對(duì)稱羥醛縮合反應(yīng)、不對(duì)稱Michael加成反應(yīng)、不對(duì)稱DielsAlder反應(yīng)等。所以，設(shè)計(jì)和開(kāi)發(fā)更多高效的金雞納生物堿衍生的有機(jī)分子催化劑，仍然是有機(jī)化學(xué)家面臨的熱點(diǎn)問(wèn)題之一。同時(shí)，許多工