手性有機小分子催化的不對稱合成反應(yīng)(參考版)
2025-02-24 10:28本頁面
【正文】 Moisan, L. Angew. Chem. Int. Ed. 2022, 43, 53185175. Acc. Chem. Res. 2022, 37 (8), Special issue. Seayad, J. List, B. Org. Biomol. Chem. 2022, 3, 719. 。 Chen, . et al. Chem. Eur. J. 2022, 12, early view. 總結(jié)與展望 ? 雙活化有機催化劑已經(jīng)初露頭角，雙活化催化具有催化劑用量較少、催化反應(yīng)適用范圍廣泛、催化劑穩(wěn)定和無毒等優(yōu)點； ? 有關(guān)雙活化催化劑的設(shè)計、合成和篩選必然會在不遠的將來成為熱點課題。 R 1 = H o r S O 2 P h3 3 9 8 % y i e l d 7 3 9 5 % e eC O O E t*S O 2 P hN H B o c?2,2amino acid Liu, .。N HN NSA rA r SH HOnu p t o 7 5 % e e u p t o 8 5 % e eLi, .。nsted AcidCatalyzed Direct Mannich Reactions Terada et al, JACS, 2022 Enantioselective Organocatalytic Reductive Amination MacMillan, JACS, 2022 Thiourea and Urea作為氫鍵活化的反應(yīng) R 1R 2 NHNHXR 1R 2 E t t e r u r e a c a t a l y s t : R 1 = N O 2 , R 2 = H , X = O S c h r e i n e r c a t a l y s t : R 1 = R 2 = C F 3 , X = SNOOONOOOc a t . c a t .NOOONOOOJacobsen’s Thiourea catalysts NON C NO HT M S C N ( 5 e q )u r e a ( 0 . 5 e q ) , C H2C l2H C l / M e O HC F3F 3 C NHNHSC F3C F 3C H OXO T M SO E t( 2 e q )u r e a ( 0 . 1 e q ) , C H 2 C l 2XO HO E tOTakamoto et al, TL, 2022 Asymmetric Michael Addition C F 3C F3NNSNE t O2C C O2E tH HO ONP hHN O 2E t O 2 C C O 2 E tC a t . ( 0 . 1 e q ) N O 2E t O 2 C C O 2 E tD C M , r tTakamoto et al, JACS, 2022, 125, 12672 up to 93% ee Catalytic Enantioselective Friedel–Crafts Reaction Up to 89% ee Ricci, Angew. Chem. Int. Ed. 2022, 44, 6576 –6579 Kiic Resolution Berkessel, Angew. Chem. Int. Ed. 2022, 44, 7466–7469 P hP hN H NSH NC F3C F3P hP hN H NSH NNNH NHN SNNH NHN SF3CF3CNNH NHN SFWorks in my group N H NSH NC F3C F3N H NSH N C F3N H NSH N FN H NSH NFFFFN H NSH NF3CC F3C F3F3C芳硫酚與不飽和羰基化合物的不對稱加成反應(yīng)研究 RR 39。 Chen, . et al, Angew. Chem. Int.
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