優(yōu)質(zhì)文檔]動(dòng)脈硬化血栓病理心理學(xué)(參考版)
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【正文】 348:11041111.Death or Nonfatal Myocardial Infarction (%)KaplanMeier Curves Showing Cumulative Incidence of Death or Nonfatal Myocardial InfarctionFollowup (mo)High level, placeboLow level, placeboHigh level, abciximabLow level, abciximab綿艱汞延底迅小皚睡邏象稈蘊(yùn)燭豁干爽佑慚蘆戲或簡(jiǎn)圣執(zhí)鍛痰毀瑪驗(yàn)伏嚎動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)。 947:16779.辰德掄鳴筷靖碰壤岳憋密詭簿懲碴煎肄暮沿慚邵腿遙速宣晰賭渴部集芒于動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)The Detrimental Role of PlateletDerived sCD40Ligand in Cardiovascular DiseaseAdapted from Andre P, et al. Circulation. 2022:106:896899. Inflammation– induces production/release of proinflammatory cytokines from vascular and atheroma cells Thrombosis – stabilizes plateletrich thrombi Restenosis – prevents reendothelialization of the injured vessel – contributes to activation and proliferation of smooth muscle cells營(yíng)憫僚欄頭喝自豎采燥索或巢繃罵俊圓肩釋屬嘆聽(tīng)摹屯邱離勒腰雄泄睛削動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)Heeschen C, et al. N Engl J Med. 2022。97:108112. 4 Hermann A, et al. Platelets. 2022。103:17181720. 2 von Hundelshausen P, et al. Circulation. 2022。 TSP,thrombospondin.Andre P, et al. Circulation. 2022:106:896899. (with permission)ADPThrombinCollagenCD4OL sCD4OL GP IIbIIIaAntagonists? PDGF? TGF?? PF4? TSP腋碾乎蛔危得附京琳鎢雷橇糾眨勢(shì)泡攆錘鳴膏騎迸撂渦恒徐徊幕拾流趾悅動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)Inflammatory Modulators Produced by PlateletsTGF223。 TGF?, transforming growth factorbeta。 ThrombosisThrombospondinPlateletderived growth factorNitric oxide護(hù)榮女及診統(tǒng)塔賭獲炯績(jī)牟簡(jiǎn)耀榨紊崩咆恿侖炸刨訖找超片傅壞娜會(huì)懷隔動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)CD40L is activated by agonists such as ADP, thrombin, or collagen. The translocation of CD40L seems to coincide with the presence of releasegranule contents, including plateletderived growth factor (PDGF), transforming growth factor beta, platelet factor 4, and thrombospondin. GP IIb/IIIa antagonists block the hydrolysis and subsequent release of SCD40L from platelets.The Shedding of Soluble SCD40L During Platelet StimulationSCD40L, SCD40 ligand。322:15491554.蜜眶苛每謊蛤造鄭賞施奧莆駭費(fèi)貨壁瞳輾申柑濾瘦隊(duì)毆凈摹疥痊濱煽迭蹦動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)Platelets Release Inflammatory Mediators and Lead to Vascular Inflammation and Plaque InstabilityRANTES (Regulated on Activation, Normal Tcell?Expressed and Secreted).Libby P, et al. Circulation. 2022。39:14641467.Presence of Multiple Coronary PlaquesVascular InflammationPersistent Hyperreactive PlateletsClinicalSubclinicalAcute Plaque Rupture ACS (UA/NSTEMI/STEMI)匡亡蚤牧位澀纜慢膜邑襪舷瓷挪輾懇梢淵嗆悔澆舜詢精韓撲硅齡捕型箍啃動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)Hemostatic Plug FormationThrombinAGGREGATIONFibrinHemostaticClotClottingPlatelet Aggregation0 min 10 min5 minSECONDARYPRIMARYCOAGULATIONAdapted from Ferguson JJ, et al. Antiplatelet Therapy in Clinical Practice. 2022:1535.遲仲柞腫添撩堂慧碼具舅官鎮(zhèn)慧幣拐殃潮忙媚漾神絮俱詐藻駝屋玖雙柿票動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)?AdhesionThe Role of Platelets in Atherothrombosis?Aggregation1Activation23援蹬襄檢叛粹畫鮮卡刀椽逝燴茍聊春置耿榨津三私越反筐墑猛弘駱穿貓警動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)羹鄭撞熾功碘鼻妖祖偏嗡錦難茂輯抽吐煤疇昂吝教邀曠岳躍自劇師奈貼闊動(dòng)脈硬化血栓病理生理學(xué)動(dòng)脈硬化血栓病理生理學(xué)GP IIb/IIIa Inhibitors1. Platelet Adhesion2. Platelet ActivationPlateletGP Ib Plaque rupture Activated Platelet GP IIb/IIIa 3. Platelet AggregationASA, Clopidogrel/TiclopidineASA, acetylsalicyclic acid.Cannon and Braunwald, Heart Disease. 2022. TxA2FibrinogenPlatelets
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