[藥學(xué)]第8章抗感染免疫-資料下載頁
2025-10-10 03:37本頁面
【正文】 ne with 4 mg ovalbumin (OVA) alone or in bination with 4, 16, 64 mg ginseng extract (GS). Values with different letters differ within the time point at P. a a a a abba a ababbbccbbbcbcbbbcbc010203040501 2 3 4 5W e e k s a f t e r s e c o n d i n j e c t i o nMultiples of antibody titersG r o u p 1 : S a l i n eG r o u p 2 : O V AG r o u p 3 : O V A + 4 m g G SG r o u p 3 : O V A + 1 6 m g G SG r o u p 5 : O V A + 6 4 m g G SMean (SD) optical density (OD) of serum antibodies against S. aureus in dairy heifers (n=6/group) immunized twice, at 0 and 14 days, with a S. aureus bacterin only (A), or the bactaerin mixed with ginseng extract (B) or ginsenoside Rb1 (C). Values with different letters differ within time point at P. * Values are significantly different from preimmunisation within group (P). a*a*a*a*a*aa*a*ab*ab*a*aba*a*b*b*a*b00 . 20 . 40 . 60 . 811 . 21 . 4p r e i m m u n 1 2 3 4 5W e e k s a f t e r t h e s e c o n d i m m u n i s a t i o nOD valueG r o u p AG r o u p BG r o u p C免疫增強藥物 左旋咪唑：對免疫功能正常的動物無效。但對免疫功能低下的動物有以下作用： – 刺激 T細(xì)胞分化，增強 T細(xì)胞對抗原的應(yīng)答。 – 增加牛巨噬細(xì)胞的 FcR，增強巨噬細(xì)胞和嗜中性白細(xì)胞的吞噬活性。 – 增加干擾素的產(chǎn)生，增強 CTL活性。 – 在慢性感染和腫瘤病的治療中起輔助作用。 維生素 干擾素 白介素 2 其他細(xì)胞因子 維生素 維生素 E缺乏可導(dǎo)致免疫抑制。補充維生素 E可提高免疫反應(yīng)。 補充維生素 E可提高豬淋巴細(xì)胞對 PWM的反應(yīng)性。 奶牛產(chǎn)前幾周通常嗜中性白細(xì)胞功能下降，巨噬細(xì)胞產(chǎn)生 IL1和表達 MHC II的功能下降。補充維生素 E可防止這種下降。 小鼠用 SRC或破傷風(fēng)類毒素免疫時，在日糧中補充維生素 E可增加抗體產(chǎn)生。 雞日糧中補充維生素 A或 E，可減少因 E 。 母雞日糧中補充維生素 E,可使被動轉(zhuǎn)移至小雞的抗體水平顯著提高。 小鼠日糧中補充維生素 E，可提高對肺炎鏈球菌的抵抗力。 Interferons rHuIFN? in treatment of bovine herpesvirus1 (BHV1) infection. Although the treated calves were less severely affected than the controls, toxic effects such as fever and depression were seen. Multiple doses were required, and some calves developed antibodies against the interfereon. rBoIFN?:BHV1. rBoIFN?: vesicular stomatitis, B. abortus。 24 hrs before E coli. challenge. IL2 rHuIL2 was administered to pigs at the same time as they received an A. pleuropneumoniae bacterin and induced a considerably greater protection on challenge. A smilar resylt was obtained using pigs immunized with a pseudorabies virus subunit vaccine. IL2 is very toxic, causing severe side effects such as diarrhea and fever.
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