【正文】 n, Lyn, Blk Tyrosine kinase Syk family: ZAP70, Syk Jak family: Jak1, Jak2, Jak3 Protein kinase Csk family: Csk Protein kinase C (PKC) Serine/threonine MAP kinase (MAP: mitogenactivation kinase protein) PI 3 kinase (PI: phosphatylinositide) Tyrosine phosphatase CD45 Protein phosphatase Serine/threonine Calcineurin 鈣調(diào)磷酸酶 phosphatase,Protein kinases and protein phosphatases in T/B activation,蛋白激酶,蛋白(d224。,鳥苷酸置換因子(yīnzǐ)：guanine nucleotide exchange factor， GEF 小G蛋白：small GTPbinding protein,第十五頁，共二十九頁。,第二十四頁，共二十九頁。NFATp。ir243。,naive CD4 T,Th0,Th2,Th1,Stat1 Tbet,Gata 3,IL12,IL4,IL12R ?1 / ?2 IFN?R1/ IFN?R2,?c IL4R,IFN ? TNF? IL2,IL 4 IL 5 IL13,CCR3, 4, 8 CxCR7,CxCR3,CCR5,Stat 4,Stat 6,Ag MHC,costimulation,ROR?t,IL17 IL 17F,Stat3,IL23,Il23R IL12R?1,Th17,IFN ?,CD4 T 細(xì)胞(x236。,第十二頁，共二十九頁。i)級(jí)聯(lián)反應(yīng),活化轉(zhuǎn)錄因子（NF?B、 NFAT、 AP1）