【正文】 tients receiving CRRT, however, marked variation in the modality, intensity, timing was observed ? Making it difficult to pare outes between patients on CRRT and those on IHD Nat. Rev. Nephrol. 2024:6:521–529. 第十四頁(yè)，共四十二頁(yè)。 Introduction ? But for several reasons parison among studies is difficult: ? Various treatment modalities have been applied in heterogeneous populations. ? Differences in clinical setting and underlying molecular biological mechanisms that initiate and maintain ARF. ? Furthermore, more than 35 definitions of ARF. ? Practice patterns vary widely between individual centers. ? Up to now, there are no standard guidelines for the application of CRRT in critically ill patients. Curr Opin Crit Care 2024。 Type of therapy Classification of blood purification in critical care (BPCC) technology PMX = polymyxinB immobilized fiber。 Timing of CRRT ?In the abovementioned studies there is a clear trend toward a better oute with earlier timing of RRT. ? In the absence of large RCTs paring early to late initiation of RRT, no firm overall remendations for timing of RRT can be made. 第二十頁(yè)，共四十二頁(yè)。 RRT in ICU: Preference ?Decision about which technique to use depends on: ?1. What we want to remove from the plasma 第三十三頁(yè)，共四十二頁(yè)。專家的意見是患者治療劑量要足夠，至少 25 ml/kg/h。 ? 多中心的 “ IVOIRE study〞 (hIgh Volume in Intensive care)，在sepsis引起的 AKI，休克和多臟衰患者中，比較 35 ml/kg/h vs. 70 ml/kg/h ，不久后，可能會(huì)對(duì)治療劑量的爭(zhēng)論有所定論。 Crit Care Med 2024, 36:610617. Kidney Int 2024,76:422427. Nat Rev Nephrol 2024, 9:521529. Clin Pharmacol Ther 2024, 86:562565. ? 目前共識(shí)： 第十六頁(yè)，共四十二頁(yè)。8:R204R212. 第五頁(yè)，共四十二頁(yè)。 Introduction ?Conclusions: ? More then 200 different definitions of ARF and about 90 RRT start criteria were reported. Oliguria and RIFLE were the most frequent criteria used to define ARF. RIFLE criteria might show a clinical impact on future daily practice and research. ? Different RRT techniques are available in most centers, but a general lack of treatment dose standardization is noted by our survey. ? Nonrenal indications to RRT still need to find a definitive role in routine practice. Nephrol Dial Transplant (2024) 21: 690–696 第六頁(yè)，共四十二頁(yè)。 Contents Introduction 1 Type of therapy 2 Timing of CRRT 3 Dose of CRRT 4 Conclusions 5 6 第十七頁(yè)，共四十二頁(yè)。 JoannesBoyau O, Honore PM: Hemofiltration Study: IVOIRE Study: clinicaltrials. gov ID NCT00241228., last Accessed in June 2024. Crit Care 2024, 13:R57. J Nephrol 2024, 24:165176. 第三十頁(yè)，共四十二頁(yè)。 Thank You 第四十二頁(yè)，共四十二頁(yè)。 Contents Introduction 1 Type of therapy 2 Timing of CRRT 3 Dose of CRRT 4 Conclusions 5 6 第三十二頁(yè)，共四十二頁(yè)