【正文】 1T ) （ 36） 式中 G—設(shè)備的質(zhì)量， kg； 1T —設(shè)備的初始溫度， ℃ ； 2T —設(shè)備的最終溫度， ℃ 。將剩余的三分之一水楊酸加入到酰化反應(yīng)釜中，重復(fù)上述操作，價格得到的乙酰水楊酸粗品用離心機(jī)過濾，得到阿司匹林粗品 [14]。 成鹽工段 在氫氧化鈉配料罐中加入氫氧化鈉固體和水，配制成 50％的氫氧化鈉溶液，打開攪拌槳，混合均勻后待用 [10]。這里水源充足，空氣清新，也是非居民區(qū)，相對人員稀少，溫度，風(fēng)力，空氣濕度等都較為適宜，而且最突出的優(yōu)點(diǎn)是交通便利，得益于齊齊哈爾鐵路運(yùn)輸相對發(fā)達(dá)。 所以車間 設(shè)備年運(yùn)轉(zhuǎn) 時間為 7 200 小時 ， 車間工作人員安排 見表 11。利用堿催化合成阿司匹林的方法原料基本不變，常用的催化劑主要有氫氧化鉀，無水碳酸鈉和乙酸鈉等。 本人簽名： 日期： 齊齊哈爾大學(xué)畢業(yè)設(shè)計（論文） I 摘 要 阿司匹林是現(xiàn)代醫(yī)學(xué)臨床上，常用的一種非甾體抗炎藥，在全世界范圍內(nèi)被廣泛應(yīng)用。 關(guān)鍵詞 ： 阿司匹林；工藝流程；車間布置 齊齊哈爾大學(xué)畢業(yè)設(shè)計（論文） II Abstract Aspirin is a monly used nonsteroidal antiinflammatory drug in modern medicine and is widely used throughout the pharmacological effects in the clinical application of the following five major aspects: pain, heat, antiinflammatory, antirheumatism and inhibition of platelet recent years, the dose of aspirin in the heart vascular disease treatment significantly increased. The task of this topic is the annual production of 300 tons of aspirin selected synthesis method is based on phenol and sodium hydroxide as raw material, after carbon dioxide carboxylation, then add concentrated sulfuric acid acidification, and finally with acetic anhydride reaction by crystallization, centrifugation and other operations to obtain aspirin main design content in addition to the process to determine, there are materials constant calculation, heat constant calculation, the main equipment selection, workshop equipment layout design, pipeline the preliminary design specifications, drawing the process flow chart, the layout of the workshop and the main equipment map. Key words： Aspirin； Process flow； Workshop layout 齊齊哈爾大學(xué)畢業(yè)設(shè)計（論文） III 目 錄 摘 要 ......................................................................................................................................... I Abstract .................................................................................................................................... II 第 1 章 緒 論 ........................................................................................................................ 1 概述 .............................................................................................................................. 1 生產(chǎn)方法簡介 ........................................................................................................ 1 設(shè)計原則及要求 .................................................................................................... 1 設(shè)計依據(jù)及設(shè)計范圍 ............................................................................................ 2 車間概況 ................................................................................................................ 2 廠址選擇 ...................................................................................................................... 3 廠址選擇原則 ........................................................................................................ 3 建廠條件 ................................................................................................................ 3 方案比較 ................................................................................................................ 3 原材料及產(chǎn)品主要技術(shù)規(guī)格 ...................................................................................... 4 原材料技術(shù)規(guī)格 .................................................................................................... 4 產(chǎn)品技術(shù)規(guī)格 ........................................................................................................ 4 原材料消耗定額及消耗量 ........................................................................................... 5 第 2 章 工藝流程設(shè)計 ............................................................................................................ 6 生產(chǎn)方法選擇 .............................................................................................................. 6 工藝流程示意圖 .......................................................................................................... 6 工藝流程敘述 .............................................................................................................. 7 成鹽工段 ................................................................................................................ 7 羧化工段 ................................................................................................................ 7 酸化 工段 ................................................................................................................ 7 ?；ざ?................................................................................................................ 7 第 3 章 化工計算 .................................................................................................................... 9 物料計算 ...................................................................................................................... 9 基礎(chǔ)數(shù)據(jù) ................................................................................................................ 9 酰化工段物料計算 ................................................................................................ 9 酸化工段物料計算 .............................................................................................. 10 羧化工段物料計算 .............................................................................................. 10 齊齊哈爾大學(xué)畢業(yè)設(shè)計（論文） IV 成鹽工段物料計算 .............................................................................................. 11 設(shè)備工藝計算 ............................................................................................................ 12 氫氧化鈉溶液配料罐 .......................................................................................... 12 成鹽反應(yīng)釜 ....................................................