【正文】 ir243。,Molsidomine 〔嗎多明〕 Inhibiting adenosine uptake and cAMP degradation Inhibiting pletelet aggregation Promoting collateral circulation after longterm use Dipyridamole 〔雙嘧達(dá)莫，潘生丁〕 Inhibiting adenosine uptake and cAMP degradation Inhibiting pletelet aggregation Promoting collateral circulation after longterm use,2. Antianginal drugs,第二十五頁(yè)，共三十一頁(yè)。,B. Clinical uses Angina pectoris: all kinds, especially stable type Heart failure：reducing heart loads due to vasodilation C. Adverse reactions Increase in heart rate and contractility Symptoms due to vasodilation: headache, flash, postural hypotension, collapse, ect. Others: methaemoglobinaemia〔高鐵血紅蛋白(xu232。,Coronary vessels: blood supply for the heart,1. OVERVIEW,第二頁(yè)，共三十一頁(yè)。,Influence of organic nitrates and dipyridamole on the blood supply of ischemic area,2. Antianginal drugs,第十二頁(yè)，共三十一頁(yè)。,Actions of calcium channel blockers,第二十二頁(yè)，共三十一頁(yè)。 ? blockers。Isosorbide dinitrate (硝酸異山梨酯)。 ?: variable according to the dose and effect of each drug 。nb225。,Ischemia (angina pectoris ): imbalance between oxygen demand and supply,第五頁(yè)，共三十一頁(yè)。,Effects of antianginal drugs: Reducing oxygen demands Reducing heart rate and contractility Dilating systemic arteries and veins ( ? wall tension by lowering heart loads) Increasing oxygen supply Dilating conduct coronary arteries ( ? coronary blood flow) Promoting regional distribution ( ? in ischemic regions) Others: Anti platelet coagulation and thrombus formation,1. OVERVIEW,第十頁(yè)，共三十一頁(yè)。 but not used for variant an