【新整理】利用生物標(biāo)志物患者急性心血管疾病(更新版)
【正文】 ture Ring structure highly conserved 11/17 amino acids are homologous Ring structure essential for physiological activity,CP11894525,Natriuretic Peptide Family Biochemistry,Cardiomyocyte,Blood,proBNP (108 aa) BNP32 (proBNP 77108),BNP32 Physiologically active form,NTproBNP 176,Secretion LV stretch Wall tension,PreproBNP (134 aa),Signal peptide (26 aa),proBNP,Serin protease (Corin?),Mair: Scand J Clin Lab Invest, 1999,CP118945210,CP118945220,97.5% percentile (pg/mL),30 3039 4049 5059 ?60,Age groups,AgeSpecific Reference Range for NTproBNP,AHJ 149(4), April 2005,pg/mL,NTproBNP,pg/mL,BNP,Weight categories (BMI),Weight categories (BMI),?25,2529.9,?30,?25,2529.9,?30,P0.001,P0.001,Values of BNP and NTproBNP by Weight,CP118945221,38 177。 1.121.93,3.42。g/L,P0.001,0.1 181。95:20532059,Antman, 1998 1.1 (0.43.5) Benamer, 1998 13.7 (3.948.3) Brisisc, 1998 8.0 (0.965.1) Cin, 1996 17.9 (5.261.2) Galvani, 1997 6.6 (1.332.3) Hamm, 1992 11.7 (3.242.6) Luscher, 1997 2.5 (1.34.8) Ohman, 1996 4.7 (1.712.7) Olatidoye, 1998 156.1 (17.41,402) Ottani, 1997 6.6 (2.022.1) Rebuzzi, 1998 25.3 (5.2123.2) Solymoss, 1997 2.4 (0.78.1) Stubbs, 1996 1.5 (0.54.2) Wu, 1995 31.5 (6.7144.9) Antman, 1996 3.8 (1.88.03),Individual Studies of Patients with“Unstable Angina” Without ST Segment Elevation,Peto OR amp。,Synergism of ECG and Elevated Troponins (PARAGON),CP10995008,JACC 41:376, 2003,6mo death/ MI rate,n=262,STdepression,P=0.20,n=125,n=259,n=174,n=57,n=82,P=0.13,P=0.15,FRISCII – GUSTO IV (Death and MI),CP114235617,James et al: Am J Med 115:181, 2003,14 12 10 8 6 4 2 0,0.01 181。 1.302.54,1.82。g/L) CKMB (3.5 181。 31,BNP Levels of Patients Diagnosed Without CHF, with Baseline Left Ventricular Dysfunction, and with CHF,BNP Levels in Heart Failure,Median BNP level (pg/mL),CP118945226,BNP Levels in Normal Subjects and Inpatients with Heart Failure,Normal,I,II,III,IV,Class,CP118945227,ED Probability of CHF Recorded,P0.0001 from clinical judgment to combined,McCullough PA et al: Circulation 106:416, 2002,Diagnostic accuracy (%),Clinical judgment,BNP,Combined,70 72 74 76 78 80 82,74.0,81.2,81.5,n=1,538,BNP Study Primary End Point,n=1,5
公司管理相關(guān)推薦
鄂ICP備17016276號(hào)-1