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n. ? Vanycin is irritating to tissue and causes necrosis and severe pain with extravasation. ? Evaluate 8th cranial nerve function by audiometry and serum Vanycin levels throughout course of therapy. ? Monitor urine: cloudy or pink urine may be signs of nephrotoxicity. Intermittent infusion ? Dilute each 500 mg vial with 10 ml of sterile water. ? Dilute further with 100 to 200 ml of IV solution (D5W) ? Infuse over 60 minutes: Do not administer rapidly or as a bolus to minimize risk of thrombophlebitis, hypotension, or red neck syndrome. ? Thrombophlebitis can be minimized by using dilute solutions of to 5 mg / ml. Neonate dosage ? Weight: kg / 5 days old ? How much Vanycin for loading dosage? ? How much Vanycin for maintenance dosage? ? How much fluid would you need to dilute medication in to administer safely? Calculations ? x 15 mg = mg ? Vanycin es in 500 mg vial ? 500 mg diluted with 10 cc sterile water ? 500mg /10 cc = ? You will draw up .97 ml ? How much fluid do you have to further dilute medication in: ( to 5 mg / ml)? ? Dilute in approximately 20 ml and run in over 60 minutes. What about the flush? ? If you put the medication and the 20 cc in the buretrol how fast will you have to set the IV pump to get the medication into the patient in 60 minutes? ? Hint: you will need 20 ml of additional fluid to flush the medication through the IV line. ? THE PHYSICIAN ORDER WILL NEVER STATE TO FLUSH THE LINE – YOU MUST DO THIS WITH EACH IV MEDICATION Practice IV medications ? Jose i