【正文】 ease, the concentration of ethyl acetate in the top product increase first and then decrease, and when the content of DMF was 30%,the ethyl acetate own the highest concentration that is %.When the content of DMF in mixed solvent lower than 30%,the main solvent EG ensure the selectivity of the mixed solvent, but added of DMF improved the solubility of the mixed solvent, so show better effect. When the content of DMF in mixed solvent higher than 30%, the selectivity of EG decreased gradually, so the effect of the mixed solvent was weakened. According to these data, we think the mixed solvent that DMF/EG= 3/7 was the best. of solvent flow rate The effects of solvent flow rate on the concentration of ethyl acetate in the top product are showed in . In the above conditions that be optimized, we investigated the effect on the reflux ratio on the concentration of ethyl acetate in the top product. From the line chart we find that the concentration of ethyl acetate in the top product increase with the increase of reflux ratio, while the reflux ratio exceed 2,the purity of the product will almost constant. On the other hand, exceed reflux ratio will bring some problems, such as extend operation time, energy needed in the tower bottom increase, influence production efficiency and so on. So we should decrease the reflux ratio in the premise of quality assurance. In that case, we chose 2 as suitable reflux ratio. We got DMF and EG as candidate solvents for acetonitrile– ethyl acetate separation through the graph principle and group contribution method bined with puteraided molecular design. The effect of the solvent was illustrated by experiment. From the result we can see that mixed solvent DMFEG has a lot of advantage than single DMF or EG solvent. Through the experiments we obtained the optimized operation parameters: the ratio of mixed solvent DMF/EG=3/7,flow rate of the mixed solvent was 20 mL/min,the reflux ratio was 2. References [1] Cheng Nenglin. Solvents handbook[M]. Beijing: Chemical Engineering . [2] Di Jiandong. Study on separation of acetonitrile and ethyl acetate mixture by batch azeotropic distillation[D].Tianjin. Tianjin University,2020. [3] Ma Wenchan, Sun Jianjie. Study on separation of acetonitrile and ethyl acetate mixture by extractive distillation. Application Chemical. 2020,39(5):781782. [4] R. Van Kaam, I. Rodr237。但兩種形成 共沸物，乙酸乙酯持有 77%和另 23%是乙腈（質(zhì)量分?jǐn)?shù)），普通精餾方法不做任何的效果。近年來，混合溶劑萃取精餾過程 [811]越來越多的應(yīng)用。目前，溶劑的選擇可以借助有效的處理計(jì)算機(jī)輔助分子設(shè)計(jì)（ CAMD） 的方法 。經(jīng)過慎重選擇我們得到的如 DMF 和溶劑是最合適的用于乙腈 –乙酸乙酯的分離。底部是一個(gè) 1500毫升瓶與開放。圖 2 顯示三溶劑都有增加的功能在產(chǎn)品乙酸乙酯濃度，破壞共沸組成。當(dāng)含 DMF混合溶劑中高于 30%，乙二醇的選擇性逐漸下降，所以混合溶劑的作用減弱。 5． 結(jié)論 我們得到了 DMF，如通過圖的原理與基團(tuán)貢獻(xiàn)法結(jié)合計(jì)算機(jī)輔助分子設(shè)計(jì) –乙酸乙酯分離的候選溶劑乙腈。通過批乙腈和乙酸乙酯的混合物的分離研究 共沸蒸餾的研究 [D]。guez當(dāng)尼斯，瑞波節(jié)。采用萃取精餾法和變壓精餾分離二丙醚和正丙醇：計(jì)算機(jī)仿真和優(yōu)化經(jīng)濟(jì)。利用間歇萃取精餾分離乙醇和水的混合溶劑的研究?；瘜W(xué)工程科學(xué)， 1998,53（ 7）： 13311348。 2020,39（ 10）： 2933. [ 10 ]李春利，李麗潔，方靜。 2020,50（ 11）：12661274 【 7】李 F M，棕 R E 萃取精餾采用混合 溶劑的烴混合物的研究 [J ]?；瘜W(xué)工程科學(xué)。天津大學(xué) 2020。從結(jié)果中我們可以看到，混合溶劑 dmfeg具有許多優(yōu)點(diǎn)，比單一溶劑 DMF或如。 溶劑流量的影響 在塔頂產(chǎn)物乙酸乙酯濃度的溶劑流量的影響表現(xiàn)在圖 4。這是由于 DMF 的強(qiáng)溶解性組合和高效的選擇性他們相互補(bǔ)充、相互促進(jìn)，從而揭示了在混合溶劑的濃度的效果更好 乙酸乙酯比單一溶劑乙腈。的流量由流量計(jì)控制。 DMF 純度為 （質(zhì)量分?jǐn)?shù)）。首先，基于改 UNIFAC 法，功能組分和預(yù)先選定 的系統(tǒng)根據(jù)一定的規(guī)則，然后自動(dòng)結(jié)