【正文】
ET保持磷酸化,這就解釋了為什么細胞能夠存活增加(圖3E)。如上圖所示(圖2BeD),MVDN30抗性細胞表達MET水平比原代細胞更高。(E)結(jié)合MET的在24小時在不存在或存在的血漿膜的熒光強度的箱圖mvdn30 R20和R80生長EBC1 WT細胞(AU:任意單位)圖2—細胞耐受性并不是由于失去了對MVDN30的敏感性。 。對抗性細胞再引入MVDN30細胞會導(dǎo)致上清液中MET ECD含量更高,與在同樣劑量處理的WT細胞相比,之后細胞內(nèi)的MET同時減少了并返回到平時觀察的抗性細胞的一半水平(圖2 D)。如圖1D所示,事實上,MVDN30的治療導(dǎo)致了再EBC1細胞中的MET通過酪氨酸酶的磷酸化消除大量減少。EBC1 肺癌細胞是MET沉癮細胞,它能放大MET的擴增、過度表達和活化過程。轉(zhuǎn)導(dǎo)細胞的可行性分析如先前描述的一樣進行,讓細胞在存在或不存在MVDN30的條件下上長72小時。254。所有的數(shù)據(jù)進行歸一化到0天的藥物治療。R80 細胞保存在有或沒有抗體(80 mg/ml)存在的條件下,而WT細胞要一直保存在有抗體的條件小16小時。hMET ex 20 Rw: 50GGGCTCCTCTTGTCATCAGC3。D 提供的通過暴露親代細胞方法來增加抗MET單價單克隆抗體的濃度。在這個研究中我們表明了不斷用MVDN30來治療沉癮癌細胞會使其具有抗性的原因是MET基因的大量復(fù)制和MET的過度表達超過了MVDN30對其有效下調(diào)并使其失去活性的的能力。在活體和動物模型進行的研究已經(jīng)表明用TKIs長期治療會導(dǎo)致機體的治療耐受性。在癌癥治療中的可以抗癌的RTKs單克隆抗體已經(jīng)被批準(zhǔn)在乳腺癌和結(jié)腸癌中使用(分別針對HER2和表皮生長因子受體)并可作為抗血管增生的藥物(針對血管內(nèi)皮生長因子受體)。癌基因和人類癌癥密切相關(guān),酪氨酸激酶起著決定性作用。結(jié)果表明一種不連續(xù)的通過抗體和化學(xué)激酶抑制劑聯(lián)合治療可能會使靶向治療的臨床反應(yīng)和對MET抗體治療旁路的抗性增加。Comment: Cost model has been widely used in the puter field as a way to evaluate whether a program is excellent or quite a number of researchers in puter field has proposed various kinds of cost models for GPU, of which most are under certain this paper give us a new perception of cost model for GPU in generalpurpose parallelization cost model for GPU can be generally applied for many application authors attempt to estimate the cost they take the GPU initialization cost, transmission of data cost as well as the program execution cost into aspect use a special algorithm to calculate the the cost is measured by the time of each this paper ,we can get through the authors’ idea very well ,because they are well organized in form and shown clearly in graphs, charts as well as in parallelization cost model is more accurate, flexible and portable than models of the we should learn the method they study a is to consider a question in a broad if we keep thinking in this way ,our ability of doing scientific research will be greatly the same time, we should keep close watch on the field of it is such an important processor that it is used widely used on modern is even considered the core graphics processor of it develops faster nowadays as the need rises.第三篇:專業(yè)英語論文翻譯MET基因復(fù)制數(shù)量的增加賦予單克隆抵抗體抗MET的能力并且建立藥物依賴性關(guān)鍵詞:MET,MVNV30單克隆抗體,酪氨酸激酶抑制劑,抗性,藥物依賴性 【摘要】:被MEI原癌基因編碼的酪氨酸激酶受體領(lǐng)導(dǎo)了具體抑制劑的發(fā)展并在癌癥中起很重要的作用,其中現(xiàn)在一些正處于前進的臨床試驗階段就以前的經(jīng)驗表明對大多數(shù)靶向治療最主要的限制是抗性的出現(xiàn)。通用計算中使用GPU來提高性能很大程度上取決于程序員的硬件知識和編程技術(shù)。s features, nice screen test for embedded smart devices, testers, test device, the plexity of the network environment and increase the efficiency of automated :《 Journal of Electronic Science and Technology》第二篇:專業(yè)英語論文翻譯A Parallelization Cost Model for GPUGPU并行成本模型 2009137127 周幼蘭AbstractUsing GPU for general puting has bee an important research direction in high performance puting , this is not a lossless optimization to the impact of device initialization cost, data transmission delay, specific characteristics of programs, and other factors, the general puting on GPU may not always achieve the desired speedup, and sometimes results in program execution performance the basis of indepth analysis of GPU internal processing mechanisms, the main factors affecting GPU implementation performance are pointed out, and a parallel cost model for GPU based on static program analysis is proposed to provide judgement basis for using GPU in general :在高性能計算技術(shù)領(lǐng)域,使用GPU執(zhí)行通用計算已成為一個重要的研究方向。來源于:《 Journal of Electronic Science and Technology》專業(yè)英語期末考查第7頁附:英文原文Embedded system research 1 IntroductionIntelligent Software Agent is the ability to perform specific tasks for the user, with a certain degree of intelligence, able to perform some tasks and autonomy in a proper manner and environment interactions software has autonomy, responsiveness, learning and social and other makes it suitable for highly dynamic environment to make a timely technology and the development of new generation mobile munication networks makes the emergence of a large number of embedded intelligent of these devices with embedded operating system support, and run an increasingly rich to test for these applications to be a need to article Intelligent Agent technology into embedded devices test, using the target device Agent, test control Agent, Network Agent and treatment were simulated test equipment, test engineers and test plexity of the environment, the use of Agent has its own characteristics, proposed An effective automated Related research and ideas of this articleAgent possess autonomy, responsiveness, learning and social and other features, makes it very suitable for handling plex problems in the test technology in the test area will already have some relevant research, the following is a specific Choi and Byoungju Choi [1] proposed a testing tool based on Agent technology, which through the use of Agent to handle user interface and test those interactions, the use of Agent to carry out the test case test case selection choices, and use the Agent for regression testing regression testing, so a good automated software they can only be made in a large number of test selection techniques select test cases has been the best use cases, write test cases can not reduce its 第8頁Other studies will Agent technology applied to a field Qi, David Hung and Eric Wong [3] proposed a Webbased Agent technology application testing technology to reduce their use of the network application testing method not only for Web application testing, but also for the testing of embedded intelligent the actual testing process, testers great task is still the preparation of various test cases, to really improve test efficiency, we must improve the general test scripts, reduce test script changes [2] [4].Common test tools for embedded smart devices(such as TestQuest)using image parison to determine the status of the target device, although this method to achieve a noninvasive test, but there are two problems, the image capture and transmission consumes a lot of test resources, the different style of phone39。測試的內(nèi)