2神經(jīng)節(jié)苷脂m1-介導(dǎo)神經(jīng)生長(zhǎng)因子(存儲(chǔ)版)
【正文】 examined elect rophysiologically and histologically 20 weeks after surgery. Results In group B and C ,the statistical difference of nerve conduction velocity (NCV) in the two sides was significant ( P 0. 05) . In group A ,NCV in N GF side was faster than that in N. S side , but no significant difference between the two sides was found. In group B and C , the number ,diameter ,myline sheath thicken and axonal diameter of the regenerating myelinated nerve in the left was greater than those in the right ,significant difference was found ( P 0. 05) . For group A ,there was no difference between two sides. The regeneration were evident in all groups. Conclusion ?、貼 GF can promote the regeneration of motor nerve ,but it s ability is limited 。神經(jīng)營(yíng)養(yǎng)因子(Neurot rophic factors ,NIFs) 對(duì)神經(jīng)再生有著重要的影響。L1戊巴比妥鈉(215 mg/ kg) ,經(jīng)耳緣靜脈注射麻醉,在兔雙側(cè)耳屏至口角連線1/ 3與此線平行作切口,鈍性分離皮下組織,顯露面神經(jīng)上下頰支及下頜緣支。完成上述步驟后,關(guān)閉創(chuàng)口。0. 03 ms) ,神經(jīng)干動(dòng)作電位波形振幅大(3112 mV 177。表1 再生神經(jīng)各項(xiàng)指標(biāo)統(tǒng)計(jì)學(xué)分析 ( x 177。 177。 177。右側(cè)也均有神經(jīng)纖維生長(zhǎng),但排列相對(duì)稀疏,神經(jīng)束及神經(jīng)纖維數(shù)量比左側(cè)少。B、C 組左右側(cè)遠(yuǎn)端再生神經(jīng)纖維的數(shù)目、纖維直徑、軸突直徑、髓鞘厚度均大于右側(cè),有顯著性差異,左側(cè)再生神經(jīng)纖維的粗纖維明顯增多,但與正常神經(jīng)纖維相比仍有差距。* 177。 177。** 177。 177。大鼠胚胎脊髓運(yùn)動(dòng)神經(jīng)元也有N GF 受體mRNA 的表達(dá),但這種表達(dá)在成體受到抑制以致難以被檢出。它的基本結(jié)構(gòu)有兩部分組成:疏水端為N2?；拾反?鑲嵌在細(xì)胞膜雙層的外層,具有脂溶性。而右側(cè)神經(jīng)纖維相對(duì)較疏散。從GM1 的結(jié)構(gòu)可以看出,它的親水端中的唾液酸與外周Ca2 + 結(jié)合能力較強(qiáng),寡糖鏈對(duì)外界刺激因子起識(shí)別和結(jié)合作用。參 考 文 獻(xiàn)[1 ] Stockel K, Schwab M , Thoenen H. Comparison between retrograde axonal trampat of nerve growth factor and tetanus toxin in motor ,sensory amp。以往認(rèn)為感覺(jué)神經(jīng)及交感神經(jīng)能夠逆行運(yùn)輸N GF ,故而N GF 能夠?qū)ζ鋼p傷后的再生起重要作用,而運(yùn)動(dòng)神經(jīng)則不能。本實(shí)驗(yàn)利用自身對(duì)照,研究GM1 介導(dǎo)N GF 對(duì)運(yùn)動(dòng)神經(jīng)元再生的影響。但是N GF 對(duì)面神經(jīng)等運(yùn)動(dòng)神經(jīng)元潛在的生物學(xué)效應(yīng)是存在的,這種效應(yīng)的發(fā)揮有賴于其他因素的介入。早期實(shí)驗(yàn)結(jié)果表明,N GF 對(duì)運(yùn)動(dòng)神經(jīng)元無(wú)顯著作用。 177。 177。 177。*1782. 00 177。 依次為4～5μ 占27 %
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