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erely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled Ca2+binding protein frequenin mediates GDNFinduced potentiation of Ca2+ channels and transmitter release, which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a longterm regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the longterm, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿寫作]某雜志給出的標(biāo)準(zhǔn)Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB] Dear Editor of the [please type in journal title or acronym]: Enclosed is a paper, entitled Mobile Agents for Network Management. Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements. 1. Title and the central theme of the article. Paper title: Mobile Agents for Network Management. This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agentbased implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agentbased network over the conventional clientserver architecture in a large network environment.2. Which subject/theme of the Journal the material fits New enabling technologies (if no matching subject/theme, enter 39。Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym]) 3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]? The necessity of having an effective puter network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has bee increasingly important today39。s bandwidth demand over the Internet, it is important for the [journal title/acronym] readers to understa