updateonarterialstiffness大動脈僵硬研究進(jìn)展(存儲版)
【正文】 + + Brachial DP (mmHg) + + Mean pressure (mmHg) + + Heart rate (bpm) + + Aortic SP (mmHg) + + Aortic DP (mmHg) + + Augmented pressure (AP) (mmHg) + + Augmentation index (AIx) (%) + + Values at the end of doubleblind treatment (3642 months) Placebo (n=119) Felodipine (n=121) p value Brachial SP (mmHg) + + Brachial DP (mmHg) + + Mean pressure (mmHg) + + Heart rate (bpm) + + Aortic SP (mmHg) + + Aortic DP (mmHg) + + Augmented pressure (AP) (mmHg) + + Augmentation index (AIx) (%) +9. 8 + Change from baseline to the end of treatment in placebo and felodipine group Placebo group Felodipine group Baseline End ? p value Baseline End ? pvalue Brachial SP (mmHg) + + + + + + Brachial DP (mmHg) + + + + + + MBP (mmHg) + + + + + + Heart rate (bpm) + + + + + + Aortic SP (mmHg) + + + + + + Aortic DP (mmHg) + + + + + + AP (mmHg) + + + + + + AIx (%) + + + + + + “ Atenolol” vs “amlodipine” CAFE study. Circulation 2020。 脈壓變化 (mmHg) 反射波增壓變化 (mmHg) 177。s Clinic, University of New South Wales, Sydney, Australia ? Heart 2020。 Arnold Hodder 2020 PWV with age Reproduced from Avalio,et al. Change in contour and amplitude of pressure waves recorded in the radial artery and carotid in normal subjects between the first and eighth decade of life Disorders with great effects on arterial stiffness ? Hypertension ? Arteriosclerosisgeneralized degeneration of medial elements in elastic arteries ? Atherosclerosis ? Diabetes mellitus ? Premature aortic degeneration ? Obesity ? All these disorders result in artery stiffening. However, to some extent, the increased arterial stiffness are reversible by treatment. Pressure/diameter relationships show schematically for an elastic artery of a normal subject(left) and an agematched patient with hypertension(right) ARTERIAL STIFFNESS amp。由于衰老動脈硬度不斷增加， PWV加快，反射波提前產(chǎn)生，落在中心動脈壓力波的收縮期而而主動脈 舒
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