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【正文】 FFA, free fatty acid。 P13K, phosphatidylinositol 3kinase。 Sons, Metabolic Syndrome and HCC ? With respect to obesity as a risk factor for HCC, the exact relation between HCC and risk still is being defined. ? Nair et al demonstrated that obesity was an independent predictor of HCC in patients with alcoholic cirrhosis and cryptogenic cirrhosis but not in patients with cirrhosis of other etiologies. ? A metaanalysis of 11 cohort studies indicated that those who were overweight had a significantly increased relative risk of developing HCC(。Metabolic Syndrome and Hepatocellular Carcinoma Li Hui Abby B. Siegel, Andrew X. Zhu. Cancer December 15, 2022, Background ? Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer death in the United States. Although many risk factors for HCC are well defined, including hepatitis B virus (HBV),hepatitis C virus (HCV), and alcohol, most series have indicated that 5% to 30% of patients with HCC lack a readily identifiable risk factor for their cancer. Metabolic syndrome ? Metabolic syndrome is a constellation of problems that includes obesity, dyslipidemia, diabetes, and insulin resistance. FIGURE 1. Components of the metabolic syndrome are shown. NAFLD indicates nonalcoholic fatty liver disease. Metabolic syndrome ? Nearly 25% of the US population meets criteria for the metabolic syndrome, and US obesity rates (body mass index [BMI] 30kg/m2) currently also exceed 25% in most regions of the country. Up to 75% of obese adults will develop fatty liver disea
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