肺癌分子靶向治療進展-全文預覽
【正文】 69 1971 1973 1975 1977 1979 1981 1983 1985 1987 1989 1991 1993 1995 1997 1999 2022 2022 2022 2022 Years Number of papers 4456 in 2022 3 in 1971 38 in 1980 198 in 1990 Angiostatin Endostatin Avastin Macugen The VEGF family are critical tumorsecreted angiogenic factors ? The vascular endothelial growth factor (VEGF) family are critical tumor secreted signaling molecules that stimulate angiogenesis and lymphangiogenesis ? There are five members of the VEGF family (VEGFA, VEGFB, VEGFC, VEGFD, VEGFE) VEGFB VEGFA VEGFE VEGFC VEGFD VEGFs bind to VEGF receptors on endothelial cells ? VEGF family members bind to surface receptors on endothelial cells ? There are three VEGF receptors: VEGFR1, VEGFR2, and VEGFR3 ? VEGFR1 and VEGFR2 stimulate angiogenesis, ? VEGFR3 stimulates angiogenesis and lymphangiogenesis VEGFR1 VEGFR2 VEGFR3 Different VEGF family members bind and activate different VEGF receptors ? VEGFR1 is activated by VEGFA and VEGFB ? VEGFR2 is activated by VEGFA, VEGFC, VEGFD, and VEGFE ? VEGFR3 is activated by VEGFC and VEGFD O’reilly MS, et al. Cell 1997。23:127 (Abs. 2022) “ 抗血管生成療法 ” 示意圖 細胞癌變 小腫瘤 腫瘤生長 分泌生長因子 誘發(fā)新生血管 新生血管向腫瘤供養(yǎng) 癌細胞通過血管擴散 腫瘤休眠 血 管 阻斷新生血管 血 管 血 管 新生血管生成與腫瘤生長、轉移的關系 Adapted from Poon RT, et al. J Clin Oncol 2022。 ?試驗研究發(fā)現(xiàn)內皮抑素 ES 具有強烈抑制血管生成的作用。 內皮抑素的作用機理 (一 ) Hajitou A, et al. FASEB J. 2022, 16(13): 18021804. Urbich C, et al.
數(shù)學相關推薦
鄂ICP備17016276號-1