[醫(yī)藥]骨髓增生異常綜合征論文：mds、aa和al患者骨髓細(xì)胞周期及增殖特征的研究-全文預(yù)覽
【正文】 nitor cells in MDS patients that can explain the dysdifferentiation and dysmaturity, which is the impaired peripheral blood cell production (cytopenias) as well as most monly a hypercellular, dysplasticappearing bone marrow. This greatly proves that the disorder of MDS might occur when the malignant damage of the haemopoietic stem/progenitor cells . There are higher percentages of G1 phase as well as the high proliferations of the CD34+ cells in both MDS and AL patients. In our study, the ratios of G0/G1 phase, CD34+, Ki67+, and Ki67+ cells in CD34+cells were all significantly higher as RAEB progressed to AL as well as RA progressed to RAEB. This indicates that the disorder of MDS evolves the different stages and may eventually have the transformation to acute leukemia because of the expansion of malignant clonal cells from the haemopoietic stem/progenitor cells or because of more and more seriously qualitative defections in cells. Both of the two disorders may have the similar pathogenesis and may be the different stage of a mon disease according to the theory of cell cycle and cell . There was no significant difference on the cell cycle b
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