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細(xì)胞凋亡與衰老(文件)

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【正文】 ays Extrinsic pathway Intrinsic pathway (1) Extrinsic pathway: Fas Signaling Pathway Fas (also called Apo1 or CD95) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Receptormediated pathway of apoptosis Bcl2 Family(cytoplasmic factors): Bad,Bid,and bax: promote apoptosis。 Morphological and biochemical characteristics of apoptosis ? Morphologi changes: Early : Chromosome condensation, cell body shrink Later : Blebbing and Nucleus and cytoplasm fragment— Apoptotic bodies At last: Phagocytosed A、 Normal cell B、 Apoptosis: Apoptotic bodies ? Biochemical characteristics of apoptosis : Apoptosis induced by Cyto C Lane 1. 0 h 2. 1 h 3. 2 h 4. 3 h 5. 4 h 6. Control 7. Marker 180~200bp DNA ladder, Accumulation of tTG, PS flipflop Contrast ofApoptosis and necrosis Apoptosis Necrosis Death by apoptosis is a neat, orderly process mechanisms of apoptosis Early researches (MIT: Robert Horrid , 1986) C. elegans:1090 cells, The Finding of CED3 mutant Without losing any of their cells to a
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