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【正文】 dy on the genetic and functional roles of the ACE on the risk of suffering a myocardial infarction in the French population. Indeed, we genotyped the rs4341 polymorphism in 531 IS cases and 549 healthy controls, and then performed functional studies by measuring serum ACE protein level and activity in healthy controls, stroke patients at baseline and stroke patients 24h after stroke symptoms onset. The results from our study did not reveal any association of the ACE variant with myocardial infarction, although it affected ACE protein level, and ischemic stroke patients showed lower ACE level than controls in the acute phase but not in the chronic phase.We believe that our findings could be of interest to the readers of European Journal of Cardiology because they bring new and strong evidence that the ACE gene and protein are not a risk factor for myocardial infarction.We hope that the editorial board will agree on the interest of this study.Sincerely yours,Sarah H. on behalf of the authors.Corresponding author: Sarah Hamilton at Cardiovascular Research Laboratory, Marie Curie Research Institute, 75000, Paris, France, xxx, phone number: +33582246xxx, fax number: +33582246xxx.Case 1Due to a direct petition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amWe would like to submit the enclosed manuscript entitled Ca2+binding protein frequenin mediates GDNFinduced potentiation of Ca2+ channels and transmitter release, which we wish to be considered for publication in Neuron.Sample Cover Letter[the example used is the IJEB]Paper title: Mobile Agents for Network Management. This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agentbased implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agentbased network over the conventional clientserver architecture in a large network environment.3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?s bandwidth demand over the Internet, it is important f
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